Genetic and Genomic Epidemiology of Stroke in People of African Ancestry

Stroke is one of the leading causes of disability and death worldwide and places a significant burden on healthcare systems. There are significant racial/ethnic differences in the incidence, subtype, and prognosis of stroke, between people of European and African ancestry, of which only about 50% ca...

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Autores principales:	Savvina Prapiadou, Stacie L. Demel, Hyacinth I. Hyacinth
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stroke genetics GWAS Africans African Americans stroke ethnic disparities Genetics QH426-470
Acceso en línea:	https://doaj.org/article/04bdd8d35fd84fedbcb2ac1412346c31
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spelling	oai:doaj.org-article:04bdd8d35fd84fedbcb2ac1412346c312021-11-25T17:42:25ZGenetic and Genomic Epidemiology of Stroke in People of African Ancestry10.3390/genes121118252073-4425https://doaj.org/article/04bdd8d35fd84fedbcb2ac1412346c312021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1825https://doaj.org/toc/2073-4425Stroke is one of the leading causes of disability and death worldwide and places a significant burden on healthcare systems. There are significant racial/ethnic differences in the incidence, subtype, and prognosis of stroke, between people of European and African ancestry, of which only about 50% can be explained by traditional stroke risk facts. However, only a small number of genetic studies include individuals of African descent, leaving many gaps in our understanding of stroke genetics among this population. This review article highlights the need for and significance of including African-ancestry individuals in stroke genetic studies and points to the efforts that have been made towards this direction. Additionally, we discuss the caveats, opportunities, and next steps in African stroke genetics—a field still in its infancy but with great potential for expanding our understanding of stroke biology and for developing new therapeutic strategies.Savvina PrapiadouStacie L. DemelHyacinth I. HyacinthMDPI AGarticlestroke geneticsGWASAfricansAfrican Americansstroke ethnic disparitiesGeneticsQH426-470ENGenes, Vol 12, Iss 1825, p 1825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke genetics GWAS Africans African Americans stroke ethnic disparities Genetics QH426-470
spellingShingle	stroke genetics GWAS Africans African Americans stroke ethnic disparities Genetics QH426-470 Savvina Prapiadou Stacie L. Demel Hyacinth I. Hyacinth Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
description	Stroke is one of the leading causes of disability and death worldwide and places a significant burden on healthcare systems. There are significant racial/ethnic differences in the incidence, subtype, and prognosis of stroke, between people of European and African ancestry, of which only about 50% can be explained by traditional stroke risk facts. However, only a small number of genetic studies include individuals of African descent, leaving many gaps in our understanding of stroke genetics among this population. This review article highlights the need for and significance of including African-ancestry individuals in stroke genetic studies and points to the efforts that have been made towards this direction. Additionally, we discuss the caveats, opportunities, and next steps in African stroke genetics—a field still in its infancy but with great potential for expanding our understanding of stroke biology and for developing new therapeutic strategies.
format	article
author	Savvina Prapiadou Stacie L. Demel Hyacinth I. Hyacinth
author_facet	Savvina Prapiadou Stacie L. Demel Hyacinth I. Hyacinth
author_sort	Savvina Prapiadou
title	Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
title_short	Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
title_full	Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
title_fullStr	Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
title_full_unstemmed	Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
title_sort	genetic and genomic epidemiology of stroke in people of african ancestry
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/04bdd8d35fd84fedbcb2ac1412346c31
work_keys_str_mv	AT savvinaprapiadou geneticandgenomicepidemiologyofstrokeinpeopleofafricanancestry AT stacieldemel geneticandgenomicepidemiologyofstrokeinpeopleofafricanancestry AT hyacinthihyacinth geneticandgenomicepidemiologyofstrokeinpeopleofafricanancestry
_version_	1718412085625356288

Genetic and Genomic Epidemiology of Stroke in People of African Ancestry

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