Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with...

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Autores principales: Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, Valerie Chew
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/04bfa3244f6242d895349149a2c716b4
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spelling oai:doaj.org-article:04bfa3244f6242d895349149a2c716b42021-12-02T14:01:26ZIntratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma10.1038/s41467-020-20171-72041-1723https://doaj.org/article/04bfa3244f6242d895349149a2c716b42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20171-7https://doaj.org/toc/2041-1723Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.Phuong H. D. NguyenSiming MaCheryl Z. J. PhuaNeslihan A. KayaHannah L. H. LaiChun Jye LimJia Qi LimMartin WasserLiyun LaiWai Leong TamTony K. H. LimWei Keat WanTracy LohWei Qiang LeowYin Huei PangChung Yip ChanSer Yee LeePeng Chung CheowHan Chong TohFlorent GinhouxShridhar IyerAlfred W. C. KowYock Young DanAlexander ChungBrian K. P. GohSalvatore AlbaniPierce K. H. ChowWeiwei ZhaiValerie ChewNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Phuong H. D. Nguyen
Siming Ma
Cheryl Z. J. Phua
Neslihan A. Kaya
Hannah L. H. Lai
Chun Jye Lim
Jia Qi Lim
Martin Wasser
Liyun Lai
Wai Leong Tam
Tony K. H. Lim
Wei Keat Wan
Tracy Loh
Wei Qiang Leow
Yin Huei Pang
Chung Yip Chan
Ser Yee Lee
Peng Chung Cheow
Han Chong Toh
Florent Ginhoux
Shridhar Iyer
Alfred W. C. Kow
Yock Young Dan
Alexander Chung
Brian K. P. Goh
Salvatore Albani
Pierce K. H. Chow
Weiwei Zhai
Valerie Chew
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
description Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.
format article
author Phuong H. D. Nguyen
Siming Ma
Cheryl Z. J. Phua
Neslihan A. Kaya
Hannah L. H. Lai
Chun Jye Lim
Jia Qi Lim
Martin Wasser
Liyun Lai
Wai Leong Tam
Tony K. H. Lim
Wei Keat Wan
Tracy Loh
Wei Qiang Leow
Yin Huei Pang
Chung Yip Chan
Ser Yee Lee
Peng Chung Cheow
Han Chong Toh
Florent Ginhoux
Shridhar Iyer
Alfred W. C. Kow
Yock Young Dan
Alexander Chung
Brian K. P. Goh
Salvatore Albani
Pierce K. H. Chow
Weiwei Zhai
Valerie Chew
author_facet Phuong H. D. Nguyen
Siming Ma
Cheryl Z. J. Phua
Neslihan A. Kaya
Hannah L. H. Lai
Chun Jye Lim
Jia Qi Lim
Martin Wasser
Liyun Lai
Wai Leong Tam
Tony K. H. Lim
Wei Keat Wan
Tracy Loh
Wei Qiang Leow
Yin Huei Pang
Chung Yip Chan
Ser Yee Lee
Peng Chung Cheow
Han Chong Toh
Florent Ginhoux
Shridhar Iyer
Alfred W. C. Kow
Yock Young Dan
Alexander Chung
Brian K. P. Goh
Salvatore Albani
Pierce K. H. Chow
Weiwei Zhai
Valerie Chew
author_sort Phuong H. D. Nguyen
title Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
title_short Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
title_full Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
title_fullStr Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
title_full_unstemmed Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
title_sort intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/04bfa3244f6242d895349149a2c716b4
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