MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to inv...

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Autores principales: Robin Ferrari, Gaëlle Martin, Oya Tagit, Alan Guichard, Alessandra Cambi, Raphaël Voituriez, Stéphane Vassilopoulos, Philippe Chavrier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/04c76045e3da42629c938074ca7418fa
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spelling oai:doaj.org-article:04c76045e3da42629c938074ca7418fa2021-12-02T17:02:10ZMT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion10.1038/s41467-019-12930-y2041-1723https://doaj.org/article/04c76045e3da42629c938074ca7418fa2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12930-yhttps://doaj.org/toc/2041-1723The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.Robin FerrariGaëlle MartinOya TagitAlan GuichardAlessandra CambiRaphaël VoituriezStéphane VassilopoulosPhilippe ChavrierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robin Ferrari
Gaëlle Martin
Oya Tagit
Alan Guichard
Alessandra Cambi
Raphaël Voituriez
Stéphane Vassilopoulos
Philippe Chavrier
MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
description The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.
format article
author Robin Ferrari
Gaëlle Martin
Oya Tagit
Alan Guichard
Alessandra Cambi
Raphaël Voituriez
Stéphane Vassilopoulos
Philippe Chavrier
author_facet Robin Ferrari
Gaëlle Martin
Oya Tagit
Alan Guichard
Alessandra Cambi
Raphaël Voituriez
Stéphane Vassilopoulos
Philippe Chavrier
author_sort Robin Ferrari
title MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
title_short MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
title_full MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
title_fullStr MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
title_full_unstemmed MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion
title_sort mt1-mmp directs force-producing proteolytic contacts that drive tumor cell invasion
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/04c76045e3da42629c938074ca7418fa
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