Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases

Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases. The mitochondria receive signals regarding the metabolic states in cells and transmit them to the...

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Autores principales:	Jin-Ho Koh, Yong-Woon Kim, Dae-Yun Seo, Tae-Seo Sohn
Formato:	article
Lenguaje:	EN
Publicado:	Korean Diabetes Association 2021
Materias:	calcium cell nucleus diabetes mellitus, type 2 endoplasmic reticulum mitochondria tfam protein Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/04ca19bf984844e4b3f4def782959192
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spelling	oai:doaj.org-article:04ca19bf984844e4b3f4def7829591922021-12-01T05:07:51ZMitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases2233-60792233-608710.4093/dmj.2021.0138https://doaj.org/article/04ca19bf984844e4b3f4def7829591922021-11-01T00:00:00Zhttp://www.e-dmj.org/upload/pdf/dmj-2021-0138.pdfhttps://doaj.org/toc/2233-6079https://doaj.org/toc/2233-6087Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases. The mitochondria receive signals regarding the metabolic states in cells and transmit them to the nucleus or endoplasmic reticulum (ER) using calcium (Ca2+) for appropriate responses. Overflux of Ca2+ in the mitochondria or dysregulation of the signaling to the nucleus and ER could increase the incidence of metabolic diseases including insulin resistance and type 2 diabetes mellitus. Mitochondrial transcription factor A (Tfam) may regulate Ca2+ flux via changing the mitochondrial membrane potential and signals to other organelles such as the nucleus and ER. Since Tfam is involved in metabolic function in the mitochondria, here, we discuss the contribution of Tfam in coordinating mitochondria-ER activities for Ca2+ flux and describe the mechanisms by which Tfam affects mitochondrial Ca2+ flux in response to metabolic challenges.Jin-Ho KohYong-Woon KimDae-Yun SeoTae-Seo SohnKorean Diabetes Associationarticlecalciumcell nucleusdiabetes mellitus, type 2endoplasmic reticulummitochondriatfam proteinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDiabetes & Metabolism Journal, Vol 45, Iss 6, Pp 853-865 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium cell nucleus diabetes mellitus, type 2 endoplasmic reticulum mitochondria tfam protein Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	calcium cell nucleus diabetes mellitus, type 2 endoplasmic reticulum mitochondria tfam protein Diseases of the endocrine glands. Clinical endocrinology RC648-665 Jin-Ho Koh Yong-Woon Kim Dae-Yun Seo Tae-Seo Sohn Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
description	Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases. The mitochondria receive signals regarding the metabolic states in cells and transmit them to the nucleus or endoplasmic reticulum (ER) using calcium (Ca2+) for appropriate responses. Overflux of Ca2+ in the mitochondria or dysregulation of the signaling to the nucleus and ER could increase the incidence of metabolic diseases including insulin resistance and type 2 diabetes mellitus. Mitochondrial transcription factor A (Tfam) may regulate Ca2+ flux via changing the mitochondrial membrane potential and signals to other organelles such as the nucleus and ER. Since Tfam is involved in metabolic function in the mitochondria, here, we discuss the contribution of Tfam in coordinating mitochondria-ER activities for Ca2+ flux and describe the mechanisms by which Tfam affects mitochondrial Ca2+ flux in response to metabolic challenges.
format	article
author	Jin-Ho Koh Yong-Woon Kim Dae-Yun Seo Tae-Seo Sohn
author_facet	Jin-Ho Koh Yong-Woon Kim Dae-Yun Seo Tae-Seo Sohn
author_sort	Jin-Ho Koh
title	Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
title_short	Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
title_full	Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
title_fullStr	Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
title_full_unstemmed	Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases
title_sort	mitochondrial tfam as a signaling regulator between cellular organelles: a perspective on metabolic diseases
publisher	Korean Diabetes Association
publishDate	2021
url	https://doaj.org/article/04ca19bf984844e4b3f4def782959192
work_keys_str_mv	AT jinhokoh mitochondrialtfamasasignalingregulatorbetweencellularorganellesaperspectiveonmetabolicdiseases AT yongwoonkim mitochondrialtfamasasignalingregulatorbetweencellularorganellesaperspectiveonmetabolicdiseases AT daeyunseo mitochondrialtfamasasignalingregulatorbetweencellularorganellesaperspectiveonmetabolicdiseases AT taeseosohn mitochondrialtfamasasignalingregulatorbetweencellularorganellesaperspectiveonmetabolicdiseases
_version_	1718405520141844480

Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases

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