Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment

The engineering of delivery systems for drugs and contrasting labels ensuring the simultaneous imaging and treatment of malignant tumors is an important hurdle in developing new tools for cancer therapy and diagnosis. Polyelectrolyte microcapsules (MCs), formed by nanosized interpolymer complexes, r...

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Autores principales:	Daria Kalenichenko, Galina Nifontova, Alexander Karaulov, Alyona Sukhanova, Igor Nabiev
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyelectrolyte microcapsules doxorubicin encapsulation quantum dots optical encoding fluorescence imaging Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/04ca337eaf18430c8df7b3b2923d3432
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spelling	oai:doaj.org-article:04ca337eaf18430c8df7b3b2923d34322021-11-25T18:32:04ZDesigning Functionalized Polyelectrolyte Microcapsules for Cancer Treatment10.3390/nano111130552079-4991https://doaj.org/article/04ca337eaf18430c8df7b3b2923d34322021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3055https://doaj.org/toc/2079-4991The engineering of delivery systems for drugs and contrasting labels ensuring the simultaneous imaging and treatment of malignant tumors is an important hurdle in developing new tools for cancer therapy and diagnosis. Polyelectrolyte microcapsules (MCs), formed by nanosized interpolymer complexes, represent a promising platform for the designing of multipurpose agents, functionalized with various components, including high- and low-molecular-weight substances, metal nanoparticles, and organic fluorescent dyes. Here, we have developed size-homogenous MCs with different structures (core/shell and shell types) and microbeads containing doxorubicin (DOX) as a model anticancer drug, and fluorescent semiconductor nanocrystals (quantum dots, QDs) as fluorescent nanolabels. In this study, we suggest approaches to the encapsulation of DOX at different stages of the MC synthesis and describe the optimal conditions for the optical encoding of MCs with water-soluble QDs. The results of primary characterization of the designed microcarriers, including particle analysis, the efficacy of DOX and QDs encapsulation, and the drug release kinetics are reported. The polyelectrolyte MCs developed here ensure a modified (prolonged) release of DOX, under conditions close to normal and tumor tissues; they possess a bright fluorescence that paves the way to their exploitation for the delivery of antitumor drugs and fluorescence imaging.Daria KalenichenkoGalina NifontovaAlexander KaraulovAlyona SukhanovaIgor NabievMDPI AGarticlepolyelectrolyte microcapsulesdoxorubicin encapsulationquantum dotsoptical encodingfluorescence imagingChemistryQD1-999ENNanomaterials, Vol 11, Iss 3055, p 3055 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyelectrolyte microcapsules doxorubicin encapsulation quantum dots optical encoding fluorescence imaging Chemistry QD1-999
spellingShingle	polyelectrolyte microcapsules doxorubicin encapsulation quantum dots optical encoding fluorescence imaging Chemistry QD1-999 Daria Kalenichenko Galina Nifontova Alexander Karaulov Alyona Sukhanova Igor Nabiev Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
description	The engineering of delivery systems for drugs and contrasting labels ensuring the simultaneous imaging and treatment of malignant tumors is an important hurdle in developing new tools for cancer therapy and diagnosis. Polyelectrolyte microcapsules (MCs), formed by nanosized interpolymer complexes, represent a promising platform for the designing of multipurpose agents, functionalized with various components, including high- and low-molecular-weight substances, metal nanoparticles, and organic fluorescent dyes. Here, we have developed size-homogenous MCs with different structures (core/shell and shell types) and microbeads containing doxorubicin (DOX) as a model anticancer drug, and fluorescent semiconductor nanocrystals (quantum dots, QDs) as fluorescent nanolabels. In this study, we suggest approaches to the encapsulation of DOX at different stages of the MC synthesis and describe the optimal conditions for the optical encoding of MCs with water-soluble QDs. The results of primary characterization of the designed microcarriers, including particle analysis, the efficacy of DOX and QDs encapsulation, and the drug release kinetics are reported. The polyelectrolyte MCs developed here ensure a modified (prolonged) release of DOX, under conditions close to normal and tumor tissues; they possess a bright fluorescence that paves the way to their exploitation for the delivery of antitumor drugs and fluorescence imaging.
format	article
author	Daria Kalenichenko Galina Nifontova Alexander Karaulov Alyona Sukhanova Igor Nabiev
author_facet	Daria Kalenichenko Galina Nifontova Alexander Karaulov Alyona Sukhanova Igor Nabiev
author_sort	Daria Kalenichenko
title	Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
title_short	Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
title_full	Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
title_fullStr	Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
title_full_unstemmed	Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment
title_sort	designing functionalized polyelectrolyte microcapsules for cancer treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/04ca337eaf18430c8df7b3b2923d3432
work_keys_str_mv	AT dariakalenichenko designingfunctionalizedpolyelectrolytemicrocapsulesforcancertreatment AT galinanifontova designingfunctionalizedpolyelectrolytemicrocapsulesforcancertreatment AT alexanderkaraulov designingfunctionalizedpolyelectrolytemicrocapsulesforcancertreatment AT alyonasukhanova designingfunctionalizedpolyelectrolytemicrocapsulesforcancertreatment AT igornabiev designingfunctionalizedpolyelectrolytemicrocapsulesforcancertreatment
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Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment

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