Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy
Abstract Calabrian Greeks are an enigmatic population that have preserved and evolved a unique variety of language, Greco, survived in the isolated Aspromonte mountain area of Southern Italy. To understand their genetic ancestry and explore possible effects of geographic and cultural isolation, we g...
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2021
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oai:doaj.org-article:04ca9099bb55400ab9d588b8c30c473e2021-12-02T14:06:56ZGenetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy10.1038/s41598-021-82591-92045-2322https://doaj.org/article/04ca9099bb55400ab9d588b8c30c473e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82591-9https://doaj.org/toc/2045-2322Abstract Calabrian Greeks are an enigmatic population that have preserved and evolved a unique variety of language, Greco, survived in the isolated Aspromonte mountain area of Southern Italy. To understand their genetic ancestry and explore possible effects of geographic and cultural isolation, we genome-wide genotyped a large set of South Italian samples including both communities that still speak Greco nowadays and those that lost the use of this language earlier in time. Comparisons with modern and ancient populations highlighted ancient, long-lasting genetic links with Eastern Mediterranean and Caucasian/Near-Eastern groups as ancestral sources of Southern Italians. Our results suggest that the Aspromonte communities might be interpreted as genetically drifted remnants that departed from such ancient genetic background as a consequence of long-term isolation. Specific patterns of population structuring and higher levels of genetic drift were indeed observed in these populations, reflecting geographic isolation amplified by cultural differences in the groups that still conserve the Greco language. Isolation and drift also affected the current genetic differentiation at specific gene pathways, prompting for future genome-wide association studies aimed at exploring trait-related loci that have drifted up in frequency in these isolated groups.Stefania SarnoRosalba PetrilliPaolo AbondioAndrea De GiovanniAlessio BoattiniMarco SazziniSara De FantiElisabetta CilliGraziella CianiDavide GentiliniDavide PettenerGiovanni RomeoCristina GiulianiDonata LuiselliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Stefania Sarno Rosalba Petrilli Paolo Abondio Andrea De Giovanni Alessio Boattini Marco Sazzini Sara De Fanti Elisabetta Cilli Graziella Ciani Davide Gentilini Davide Pettener Giovanni Romeo Cristina Giuliani Donata Luiselli Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| description |
Abstract Calabrian Greeks are an enigmatic population that have preserved and evolved a unique variety of language, Greco, survived in the isolated Aspromonte mountain area of Southern Italy. To understand their genetic ancestry and explore possible effects of geographic and cultural isolation, we genome-wide genotyped a large set of South Italian samples including both communities that still speak Greco nowadays and those that lost the use of this language earlier in time. Comparisons with modern and ancient populations highlighted ancient, long-lasting genetic links with Eastern Mediterranean and Caucasian/Near-Eastern groups as ancestral sources of Southern Italians. Our results suggest that the Aspromonte communities might be interpreted as genetically drifted remnants that departed from such ancient genetic background as a consequence of long-term isolation. Specific patterns of population structuring and higher levels of genetic drift were indeed observed in these populations, reflecting geographic isolation amplified by cultural differences in the groups that still conserve the Greco language. Isolation and drift also affected the current genetic differentiation at specific gene pathways, prompting for future genome-wide association studies aimed at exploring trait-related loci that have drifted up in frequency in these isolated groups. |
| format |
article |
| author |
Stefania Sarno Rosalba Petrilli Paolo Abondio Andrea De Giovanni Alessio Boattini Marco Sazzini Sara De Fanti Elisabetta Cilli Graziella Ciani Davide Gentilini Davide Pettener Giovanni Romeo Cristina Giuliani Donata Luiselli |
| author_facet |
Stefania Sarno Rosalba Petrilli Paolo Abondio Andrea De Giovanni Alessio Boattini Marco Sazzini Sara De Fanti Elisabetta Cilli Graziella Ciani Davide Gentilini Davide Pettener Giovanni Romeo Cristina Giuliani Donata Luiselli |
| author_sort |
Stefania Sarno |
| title |
Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| title_short |
Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| title_full |
Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| title_fullStr |
Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| title_full_unstemmed |
Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy |
| title_sort |
genetic history of calabrian greeks reveals ancient events and long term isolation in the aspromonte area of southern italy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/04ca9099bb55400ab9d588b8c30c473e |
| work_keys_str_mv |
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