Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery
We have developed an in vitro system to easily examine the affinity for vitamin D receptor (VDR) and CYP24A1-mediated metabolism as two methods of assessing vitamin D derivatives. Vitamin D derivatives with high VDR affinity and resistance to CYP24A1-mediated metabolism could be good therapeutic age...
Guardado en:
Autores principales: | Kaori Yasuda, Miyu Nishikawa, Hiroki Mano, Masashi Takano, Atsushi Kittaka, Shinichi Ikushiro, Toshiyuki Sakaki |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/04cd20e66f75432db5ef07d3d6fde473 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism
por: Fumihiro Kawagoe, et al.
Publicado: (2021) -
Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
por: Laura Elena Pineda Lancheros, et al.
Publicado: (2021) -
Assessment of Practice and Factors associated with Sunlight Exposure of Infants among Mothers in Debre Berhan Town, North Shewa Zone, Amhara Region, Ethiopia
por: Teklehaimanot WZ, et al.
Publicado: (2021) -
Bone Health in School Age Children: Effects of Nutritional Intake on Outcomes
por: Steven A. Abrams
Publicado: (2021) -
MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity
por: Shanshan Liang, et al.
Publicado: (2021)