Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review

Background: Vascular cognitive impairment (VCI) is a major public health problem. The current diagnosis of VCI is made based on the assessment of clinical symptoms and neuropsychological measurements, and is supported by neuroimaging. These methods are both time-consuming and expensive, which leads...

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Autores principales:	Qi Qin, Yunsi Yin, Yi Xing, Xuan Wang, Yan Wang, Fan Wang, Yi Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lipid metabolism vascular cognitive impairment (VCI) brain lipids diagnostic biomarkers peripheral biomarkers Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/04ce9a7b3a8343209cdeb598c81ed508
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spelling	oai:doaj.org-article:04ce9a7b3a8343209cdeb598c81ed5082021-11-19T04:33:27ZLipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review1664-229510.3389/fneur.2021.709134https://doaj.org/article/04ce9a7b3a8343209cdeb598c81ed5082021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.709134/fullhttps://doaj.org/toc/1664-2295Background: Vascular cognitive impairment (VCI) is a major public health problem. The current diagnosis of VCI is made based on the assessment of clinical symptoms and neuropsychological measurements, and is supported by neuroimaging. These methods are both time-consuming and expensive, which leads to needs for alternative biomarkers for VCI. Metabolomics is an emerging and powerful tool to discover of new biomarkers of disease, which can investigate variations in different metabolic processes such as lipid, since the brain is highly enriched in lipids and that lipid changes may lead to pathology in the brain. Vascular cognitive impairment is vulnerable to the disturbance of lipid metabolism. Furthermore, blood samples, which could be identified as reliable clinical biomarkers are relatively convenient to obtain and provide a non-invasive assessment. Therefore, our study aims to understand whether peripheral lipid biomarkers can be used as diagnostic biomarkers and monitor the progression of VCI.Methods: We systematically searched the PubMed, Embase, CNKI, and VIP databases to find VCI and lipid metabolism in reports from inception through February 2021. Studies meeting the following criteria were eligible: (1) original studies in humans; (2) lipid metabolites in blood; (3) reports of VCI.Results: Through our review, nine original articles were eligible. Blood-based metabolites that might be potential biomarkers were identified. Most of them including PC, PE, Cers, and ChEs were significantly lower, while elevation of FAs and DGs were associated with VCI. Most importantly, these blood-based metabolites might be proposed as potential biomarkers for VCI, which provides direction for further validation.Discussion and Conclusion: To the best of our knowledge, this is the first systemic review concerning the relationship of lipid metabolism and VCI. It identifies potential biomarkers and provides insights into the disease pathobiology. However, more advanced studies and researches on a lipidomic platform must be done to understand the exact pathology behind and identify potential lipid biomarkers, which might help achieve the goal of discovering novel therapeutics.Qi QinYunsi YinYi XingXuan WangYan WangFan WangYi TangYi TangFrontiers Media S.A.articlelipid metabolismvascular cognitive impairment (VCI)brain lipidsdiagnostic biomarkersperipheral biomarkersNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid metabolism vascular cognitive impairment (VCI) brain lipids diagnostic biomarkers peripheral biomarkers Neurology. Diseases of the nervous system RC346-429
spellingShingle	lipid metabolism vascular cognitive impairment (VCI) brain lipids diagnostic biomarkers peripheral biomarkers Neurology. Diseases of the nervous system RC346-429 Qi Qin Yunsi Yin Yi Xing Xuan Wang Yan Wang Fan Wang Yi Tang Yi Tang Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
description	Background: Vascular cognitive impairment (VCI) is a major public health problem. The current diagnosis of VCI is made based on the assessment of clinical symptoms and neuropsychological measurements, and is supported by neuroimaging. These methods are both time-consuming and expensive, which leads to needs for alternative biomarkers for VCI. Metabolomics is an emerging and powerful tool to discover of new biomarkers of disease, which can investigate variations in different metabolic processes such as lipid, since the brain is highly enriched in lipids and that lipid changes may lead to pathology in the brain. Vascular cognitive impairment is vulnerable to the disturbance of lipid metabolism. Furthermore, blood samples, which could be identified as reliable clinical biomarkers are relatively convenient to obtain and provide a non-invasive assessment. Therefore, our study aims to understand whether peripheral lipid biomarkers can be used as diagnostic biomarkers and monitor the progression of VCI.Methods: We systematically searched the PubMed, Embase, CNKI, and VIP databases to find VCI and lipid metabolism in reports from inception through February 2021. Studies meeting the following criteria were eligible: (1) original studies in humans; (2) lipid metabolites in blood; (3) reports of VCI.Results: Through our review, nine original articles were eligible. Blood-based metabolites that might be potential biomarkers were identified. Most of them including PC, PE, Cers, and ChEs were significantly lower, while elevation of FAs and DGs were associated with VCI. Most importantly, these blood-based metabolites might be proposed as potential biomarkers for VCI, which provides direction for further validation.Discussion and Conclusion: To the best of our knowledge, this is the first systemic review concerning the relationship of lipid metabolism and VCI. It identifies potential biomarkers and provides insights into the disease pathobiology. However, more advanced studies and researches on a lipidomic platform must be done to understand the exact pathology behind and identify potential lipid biomarkers, which might help achieve the goal of discovering novel therapeutics.
format	article
author	Qi Qin Yunsi Yin Yi Xing Xuan Wang Yan Wang Fan Wang Yi Tang Yi Tang
author_facet	Qi Qin Yunsi Yin Yi Xing Xuan Wang Yan Wang Fan Wang Yi Tang Yi Tang
author_sort	Qi Qin
title	Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
title_short	Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
title_full	Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
title_fullStr	Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
title_full_unstemmed	Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review
title_sort	lipid metabolism in the development and progression of vascular cognitive impairment: a systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/04ce9a7b3a8343209cdeb598c81ed508
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Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review

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