HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers

As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it can be de novo expressed. It is now widely accep...

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Autores principales:	Peilong Li, Nan Wang, Yi Zhang, Chuanxin Wang, Lutao Du
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HLA-G tumor immune escape extracellular vesicles biomarker Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/04d3664803d64c95b49f278588a4e6eb
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spelling	oai:doaj.org-article:04d3664803d64c95b49f278588a4e6eb2021-11-11T10:23:04ZHLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers1664-322410.3389/fimmu.2021.791535https://doaj.org/article/04d3664803d64c95b49f278588a4e6eb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.791535/fullhttps://doaj.org/toc/1664-3224As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it can be de novo expressed. It is now widely accepted that HLA-G is a key molecule in the process of immune escape of cancer cells, which is ubiquitously expressed in the tumor environment. This raises the possibility that it may play an adverse role in tumor immunity. The expression level of HLA-G has been demonstrated to be highly correlated with clinical parameters in many tumors, and its potential significance in the diagnosis and prognosis of cancer has been postulated. However, because HLA-G itself has up to seven different subtypes, and for some subtypes, detected antibodies are few or absent, it is hard to evaluate the actual expression of HLA-G in tumors. In the present work, we described (a) the structure and three main forms of HLA-G, (b) summarized the mechanism of HLA-G in the immune escape of tumor cells, (c) discussed the potential role of HLA-G as a tumor marker, and reviewed (d) the methods for detecting and quantifying HLA-G.Peilong LiPeilong LiPeilong LiNan WangYi ZhangChuanxin WangChuanxin WangChuanxin WangLutao DuLutao DuLutao DuFrontiers Media S.A.articleHLA-Gtumorimmune escapeextracellular vesiclesbiomarkerImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HLA-G tumor immune escape extracellular vesicles biomarker Immunologic diseases. Allergy RC581-607
spellingShingle	HLA-G tumor immune escape extracellular vesicles biomarker Immunologic diseases. Allergy RC581-607 Peilong Li Peilong Li Peilong Li Nan Wang Yi Zhang Chuanxin Wang Chuanxin Wang Chuanxin Wang Lutao Du Lutao Du Lutao Du HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
description	As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it can be de novo expressed. It is now widely accepted that HLA-G is a key molecule in the process of immune escape of cancer cells, which is ubiquitously expressed in the tumor environment. This raises the possibility that it may play an adverse role in tumor immunity. The expression level of HLA-G has been demonstrated to be highly correlated with clinical parameters in many tumors, and its potential significance in the diagnosis and prognosis of cancer has been postulated. However, because HLA-G itself has up to seven different subtypes, and for some subtypes, detected antibodies are few or absent, it is hard to evaluate the actual expression of HLA-G in tumors. In the present work, we described (a) the structure and three main forms of HLA-G, (b) summarized the mechanism of HLA-G in the immune escape of tumor cells, (c) discussed the potential role of HLA-G as a tumor marker, and reviewed (d) the methods for detecting and quantifying HLA-G.
format	article
author	Peilong Li Peilong Li Peilong Li Nan Wang Yi Zhang Chuanxin Wang Chuanxin Wang Chuanxin Wang Lutao Du Lutao Du Lutao Du
author_facet	Peilong Li Peilong Li Peilong Li Nan Wang Yi Zhang Chuanxin Wang Chuanxin Wang Chuanxin Wang Lutao Du Lutao Du Lutao Du
author_sort	Peilong Li
title	HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
title_short	HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
title_full	HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
title_fullStr	HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
title_full_unstemmed	HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
title_sort	hla-g/shla-g and hla-g-bearing extracellular vesicles in cancers: potential role as biomarkers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/04d3664803d64c95b49f278588a4e6eb
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HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers

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