Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk

Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. I. Dimitriadis, G. Perry, S. F. Foley, K. E. Tansey, D. K. Jones, P. Holmans, S. Zammit, J. Hall, M. C. O’Donovan, M. J. Owen, K. D. Singh, D. E. Linden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:04d7fcdfd1884d62becdc5bcbe76590d
record_format	dspace
spelling	oai:doaj.org-article:04d7fcdfd1884d62becdc5bcbe76590d2021-11-21T12:07:44ZGenetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk10.1038/s41398-021-01678-z2158-3188https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01678-zhttps://doaj.org/toc/2158-3188Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma oscillation estimates, both at sensor and source level. Recent studies have reported a deficit of visual gamma activity in schizophrenia patients, in medication naive subjects, and high-risk clinical participants, but the genetic contribution to such a deficit has remained unresolved. Here, for the first time, we use a genetic risk score approach to assess the relationship between genetic risk for schizophrenia and visual gamma activity in a population-based sample drawn from a birth cohort. We compared visual gamma activity in a group (N = 104) with a high genetic risk profile score for schizophrenia (SCZ-PRS) to a group with low SCZ-PRS (N = 99). Source-reconstructed V1 activity was extracted using beamformer analysis applied to MEG recordings using individual MRI scans. No group differences were found in the induced gamma peak amplitude or peak frequency. However, a non-parametric statistical contrast of the response spectrum revealed more robust group differences in the amplitude of high-beta/gamma power across the frequency range, suggesting that overall spectral shape carries important biological information beyond the individual frequency peak. Our findings show that changes in gamma band activity correlate with liability to schizophrenia and suggest that the index changes to synaptic function and neuronal firing patterns that are of pathophysiological relevance rather than consequences of the disorder.S. I. DimitriadisG. PerryS. F. FoleyK. E. TanseyD. K. JonesP. HolmansS. ZammitJ. HallM. C. O’DonovanM. J. OwenK. D. SinghD. E. LindenNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 S. I. Dimitriadis G. Perry S. F. Foley K. E. Tansey D. K. Jones P. Holmans S. Zammit J. Hall M. C. O’Donovan M. J. Owen K. D. Singh D. E. Linden Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
description	Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma oscillation estimates, both at sensor and source level. Recent studies have reported a deficit of visual gamma activity in schizophrenia patients, in medication naive subjects, and high-risk clinical participants, but the genetic contribution to such a deficit has remained unresolved. Here, for the first time, we use a genetic risk score approach to assess the relationship between genetic risk for schizophrenia and visual gamma activity in a population-based sample drawn from a birth cohort. We compared visual gamma activity in a group (N = 104) with a high genetic risk profile score for schizophrenia (SCZ-PRS) to a group with low SCZ-PRS (N = 99). Source-reconstructed V1 activity was extracted using beamformer analysis applied to MEG recordings using individual MRI scans. No group differences were found in the induced gamma peak amplitude or peak frequency. However, a non-parametric statistical contrast of the response spectrum revealed more robust group differences in the amplitude of high-beta/gamma power across the frequency range, suggesting that overall spectral shape carries important biological information beyond the individual frequency peak. Our findings show that changes in gamma band activity correlate with liability to schizophrenia and suggest that the index changes to synaptic function and neuronal firing patterns that are of pathophysiological relevance rather than consequences of the disorder.
format	article
author	S. I. Dimitriadis G. Perry S. F. Foley K. E. Tansey D. K. Jones P. Holmans S. Zammit J. Hall M. C. O’Donovan M. J. Owen K. D. Singh D. E. Linden
author_facet	S. I. Dimitriadis G. Perry S. F. Foley K. E. Tansey D. K. Jones P. Holmans S. Zammit J. Hall M. C. O’Donovan M. J. Owen K. D. Singh D. E. Linden
author_sort	S. I. Dimitriadis
title	Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
title_short	Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
title_full	Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
title_fullStr	Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
title_full_unstemmed	Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
title_sort	genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d
work_keys_str_mv	AT sidimitriadis geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT gperry geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT sffoley geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT ketansey geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT dkjones geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT pholmans geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT szammit geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT jhall geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT mcodonovan geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT mjowen geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT kdsingh geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk AT delinden geneticriskforschizophreniaisassociatedwithalteredvisuallyinducedgammabandactivityevidencefromapopulationsamplestratifiedpolygenicrisk
_version_	1718419165777231872

Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk

Ejemplares similares