The changes of cerebral morphology related to aging in Taiwanese population.

A cross-sectional study with the 3-dimensional (3D) MRI reconstruction technique was conducted to investigate cerebral complexity changes related to age differences in native Taiwanese population. In our sample of 85 participants aged between 25 and 81, age was associated with gradual ventricular ex...

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Autores principales:	Hsiao-Lan Sharon Wang, Rongjun Yu, Yu-Tzu Wu, Wen-Yuan Lee, Ming-Fan Lin, Chia-Yuan Chen, Ein-Yiao Shen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04e62f8e3b264f1c931422954600fded
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spelling	oai:doaj.org-article:04e62f8e3b264f1c931422954600fded2021-11-18T08:00:14ZThe changes of cerebral morphology related to aging in Taiwanese population.1932-620310.1371/journal.pone.0055241https://doaj.org/article/04e62f8e3b264f1c931422954600fded2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23358658/?tool=EBIhttps://doaj.org/toc/1932-6203A cross-sectional study with the 3-dimensional (3D) MRI reconstruction technique was conducted to investigate cerebral complexity changes related to age differences in native Taiwanese population. In our sample of 85 participants aged between 25 and 81, age was associated with gradual ventricular expansion. A nonlinear quadratic relationship between white matter volume and age was found overall in the brain. Widespread age-related reduction in white matter was detected from late adulthood onwards. However, no significant age-related changes in the cortex and whole brain volume were determined throughout adulthood. These findings provided information in describing brain structural complexity, which might in the future serve as an objective diagnostic index or as a predictive parameter for neurological diseases. Our method then may be used for cross-cultural longitudinal studies to evaluate the effect of disease, environment and aging on the brain.Hsiao-Lan Sharon WangRongjun YuYu-Tzu WuWen-Yuan LeeMing-Fan LinChia-Yuan ChenEin-Yiao ShenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e55241 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsiao-Lan Sharon Wang Rongjun Yu Yu-Tzu Wu Wen-Yuan Lee Ming-Fan Lin Chia-Yuan Chen Ein-Yiao Shen The changes of cerebral morphology related to aging in Taiwanese population.
description	A cross-sectional study with the 3-dimensional (3D) MRI reconstruction technique was conducted to investigate cerebral complexity changes related to age differences in native Taiwanese population. In our sample of 85 participants aged between 25 and 81, age was associated with gradual ventricular expansion. A nonlinear quadratic relationship between white matter volume and age was found overall in the brain. Widespread age-related reduction in white matter was detected from late adulthood onwards. However, no significant age-related changes in the cortex and whole brain volume were determined throughout adulthood. These findings provided information in describing brain structural complexity, which might in the future serve as an objective diagnostic index or as a predictive parameter for neurological diseases. Our method then may be used for cross-cultural longitudinal studies to evaluate the effect of disease, environment and aging on the brain.
format	article
author	Hsiao-Lan Sharon Wang Rongjun Yu Yu-Tzu Wu Wen-Yuan Lee Ming-Fan Lin Chia-Yuan Chen Ein-Yiao Shen
author_facet	Hsiao-Lan Sharon Wang Rongjun Yu Yu-Tzu Wu Wen-Yuan Lee Ming-Fan Lin Chia-Yuan Chen Ein-Yiao Shen
author_sort	Hsiao-Lan Sharon Wang
title	The changes of cerebral morphology related to aging in Taiwanese population.
title_short	The changes of cerebral morphology related to aging in Taiwanese population.
title_full	The changes of cerebral morphology related to aging in Taiwanese population.
title_fullStr	The changes of cerebral morphology related to aging in Taiwanese population.
title_full_unstemmed	The changes of cerebral morphology related to aging in Taiwanese population.
title_sort	changes of cerebral morphology related to aging in taiwanese population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/04e62f8e3b264f1c931422954600fded
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The changes of cerebral morphology related to aging in Taiwanese population.

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