Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

Abstract Lifespan in many organisms, including Drosophila melanogaster, can be increased by reduced insulin-IGF-like signaling (IIS) or by changes in diet. Most studies testing whether IIS is involved in diet-mediated lifespan extension employ only a few diets, but recent data shows that a broad ran...

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Autores principales:	Jelle Zandveld, Joost van den Heuvel, Bastiaan J. Zwaan, Matthew D.W. Piper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/04e7197a959a4b37b839507462b5f7f3
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id	oai:doaj.org-article:04e7197a959a4b37b839507462b5f7f3
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spelling	oai:doaj.org-article:04e7197a959a4b37b839507462b5f7f32021-12-02T13:41:46ZBoth overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster10.1038/s41514-017-0004-02056-3973https://doaj.org/article/04e7197a959a4b37b839507462b5f7f32017-02-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0004-0https://doaj.org/toc/2056-3973Abstract Lifespan in many organisms, including Drosophila melanogaster, can be increased by reduced insulin-IGF-like signaling (IIS) or by changes in diet. Most studies testing whether IIS is involved in diet-mediated lifespan extension employ only a few diets, but recent data shows that a broad range of nutritional environments is required. Here, we present lifespan data of long-lived Drosophila, lacking three of the eight insulin-like peptides [Drosophila insulin-like peptides 2,3,5 (dilp2-3,5)] on nine different diets that surround the optimum for lifespan. Their nutritional content was varied by manipulating sugar and yeast concentrations independently, and thus incorporated changes in both diet restriction and nutrient balance. The mutants were substantially longer-lived than controls on every diet, but the effects on the lifespan response to sugar and yeast differed. Our data illustrates how a greater coverage of diet balance (DB) and restriction can unify differing interpretations of how IIS might be involved in the response of lifespan to diet.Jelle ZandveldJoost van den HeuvelBastiaan J. ZwaanMatthew D.W. PiperNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Jelle Zandveld Joost van den Heuvel Bastiaan J. Zwaan Matthew D.W. Piper Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
description	Abstract Lifespan in many organisms, including Drosophila melanogaster, can be increased by reduced insulin-IGF-like signaling (IIS) or by changes in diet. Most studies testing whether IIS is involved in diet-mediated lifespan extension employ only a few diets, but recent data shows that a broad range of nutritional environments is required. Here, we present lifespan data of long-lived Drosophila, lacking three of the eight insulin-like peptides [Drosophila insulin-like peptides 2,3,5 (dilp2-3,5)] on nine different diets that surround the optimum for lifespan. Their nutritional content was varied by manipulating sugar and yeast concentrations independently, and thus incorporated changes in both diet restriction and nutrient balance. The mutants were substantially longer-lived than controls on every diet, but the effects on the lifespan response to sugar and yeast differed. Our data illustrates how a greater coverage of diet balance (DB) and restriction can unify differing interpretations of how IIS might be involved in the response of lifespan to diet.
format	article
author	Jelle Zandveld Joost van den Heuvel Bastiaan J. Zwaan Matthew D.W. Piper
author_facet	Jelle Zandveld Joost van den Heuvel Bastiaan J. Zwaan Matthew D.W. Piper
author_sort	Jelle Zandveld
title	Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
title_short	Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
title_full	Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
title_fullStr	Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
title_full_unstemmed	Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster
title_sort	both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of drosophila melanogaster
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/04e7197a959a4b37b839507462b5f7f3
work_keys_str_mv	AT jellezandveld bothoverlappingandindependentmechanismsdeterminehowdietandinsulinligandknockoutsextendlifespanofdrosophilamelanogaster AT joostvandenheuvel bothoverlappingandindependentmechanismsdeterminehowdietandinsulinligandknockoutsextendlifespanofdrosophilamelanogaster AT bastiaanjzwaan bothoverlappingandindependentmechanismsdeterminehowdietandinsulinligandknockoutsextendlifespanofdrosophilamelanogaster AT matthewdwpiper bothoverlappingandindependentmechanismsdeterminehowdietandinsulinligandknockoutsextendlifespanofdrosophilamelanogaster
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Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

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