Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts

Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts

Heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV) dysfunction are frequent complications of diabetic cardiomyopathy. Here we aimed to characterize RV and left ventricular (LV) remodeling and its prevention by vardenafil (a long-acting phosphodiesterase-5A (PDE-5A) inh...

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Main Authors: Beáta Bódi, Árpád Kovács, Hajnalka Gulyás, Lilla Mártha, Attila Tóth, Csaba Mátyás, Bálint András Barta, Attila Oláh, Béla Merkely, Tamás Radovits, Zoltán Papp
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
right ventricle
HFpEF
diabetic cardiomyopathy
cardiomyocyte passive tension
Ca<sup>2+</sup>-sensitivity of force production
myofilament protein phosphorylation
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/04ef2fffcc6544f4a0bdcdfbf7c8833a
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https://doaj.org/article/04ef2fffcc6544f4a0bdcdfbf7c8833a

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