OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection

During herpesvirus infection, most individuals intrinsically suppress a primary infection and therewith preclude potential damage or neurodegeneration of the CNS. Here, Ames et al. show that Optineurin (OPTN), a conserved autophagy receptor, restricts HSV-1 spread, degrades viral VP16 through autoph...

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Auteurs principaux:	Joshua Ames, Tejabhiram Yadavalli, Rahul Suryawanshi, James Hopkins, Alexander Agelidis, Chandrashekhar Patil, Brian Fredericks, Henry Tseng, Tibor Valyi-Nagy, Deepak Shukla
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/04effd8ca26d4bee869ab8aa1646df51
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id	oai:doaj.org-article:04effd8ca26d4bee869ab8aa1646df51
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spelling	oai:doaj.org-article:04effd8ca26d4bee869ab8aa1646df512021-12-02T18:02:07ZOPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection10.1038/s41467-021-25642-z2041-1723https://doaj.org/article/04effd8ca26d4bee869ab8aa1646df512021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25642-zhttps://doaj.org/toc/2041-1723During herpesvirus infection, most individuals intrinsically suppress a primary infection and therewith preclude potential damage or neurodegeneration of the CNS. Here, Ames et al. show that Optineurin (OPTN), a conserved autophagy receptor, restricts HSV-1 spread, degrades viral VP16 through autophagy and is neuroprotective against HSV infection in vivo.Joshua AmesTejabhiram YadavalliRahul SuryawanshiJames HopkinsAlexander AgelidisChandrashekhar PatilBrian FredericksHenry TsengTibor Valyi-NagyDeepak ShuklaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua Ames Tejabhiram Yadavalli Rahul Suryawanshi James Hopkins Alexander Agelidis Chandrashekhar Patil Brian Fredericks Henry Tseng Tibor Valyi-Nagy Deepak Shukla OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
description	During herpesvirus infection, most individuals intrinsically suppress a primary infection and therewith preclude potential damage or neurodegeneration of the CNS. Here, Ames et al. show that Optineurin (OPTN), a conserved autophagy receptor, restricts HSV-1 spread, degrades viral VP16 through autophagy and is neuroprotective against HSV infection in vivo.
format	article
author	Joshua Ames Tejabhiram Yadavalli Rahul Suryawanshi James Hopkins Alexander Agelidis Chandrashekhar Patil Brian Fredericks Henry Tseng Tibor Valyi-Nagy Deepak Shukla
author_facet	Joshua Ames Tejabhiram Yadavalli Rahul Suryawanshi James Hopkins Alexander Agelidis Chandrashekhar Patil Brian Fredericks Henry Tseng Tibor Valyi-Nagy Deepak Shukla
author_sort	Joshua Ames
title	OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
title_short	OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
title_full	OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
title_fullStr	OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
title_full_unstemmed	OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
title_sort	optn is a host intrinsic restriction factor against neuroinvasive hsv-1 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04effd8ca26d4bee869ab8aa1646df51
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_version_	1718378908466806784

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection

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