Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model

Abstract We evaluated trajectories of glycated hemoglobin (HbA1c) levels and body mass index z-scores (BMIz) for 5 years after diagnosis among Korean children and adolescents with type 1 diabetes (T1D) or type 2 diabetes (T2D) using the common data model. From the de-identified database of three hos...

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Autores principales:	Yun Jeong Lee, Sooyoung Yoo, Soyoung Yi, Seok Kim, Chunggak Lee, Jihoon Cho, Soyeon Ahn, Sunkyu Choi, Hee Hwang, Young Ah Lee, Choong Ho Shin, Hyung-Jin Yoon, Kwangsoo Kim, Eunhye Song, Jin Ho Choi, Han Wook Yoo, Young-Hak Kim, Ji Seon Oh, Eun-Ae Kang, Ga Kyoung Baek, Jae Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04f08118a6e5489fbb7a79e79f702eb2
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spelling	oai:doaj.org-article:04f08118a6e5489fbb7a79e79f702eb22021-12-02T16:08:08ZTrajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model10.1038/s41598-021-94194-52045-2322https://doaj.org/article/04f08118a6e5489fbb7a79e79f702eb22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94194-5https://doaj.org/toc/2045-2322Abstract We evaluated trajectories of glycated hemoglobin (HbA1c) levels and body mass index z-scores (BMIz) for 5 years after diagnosis among Korean children and adolescents with type 1 diabetes (T1D) or type 2 diabetes (T2D) using the common data model. From the de-identified database of three hospitals, 889 patients < 15 years of age diagnosed with T1D or T2D (393 boys, 664 T1D patients) were enrolled. Diagnosis was defined as first exposure to antidiabetic drug at each center. Compared with T2D patients, T1D patients had lower BMIz at diagnosis (− 0.4 ± 1.2 vs. 1.5 ± 1.4, p < 0.001) and 3 months (− 0.1 ± 1.0 vs. 1.5 ± 1.5, p < 0.001), and higher HbA1c levels at diagnosis (10.0 ± 2.6% vs. 9.5 ± 2.7%, p < 0.01). After 3 months, HbA1c levels reached a nadir of 7.6% and 6.5% in T1D and T2D patients, respectively, followed by progressive increases; only 10.4% of T1D and 29.7% of T2D patients achieved the recommended HbA1c target (< 7.0%) at 60 months. T1D patients showed consistent increases in BMIz; T2D patients showed no significant change in BMIz during follow-up. Peri-pubertal girls with T1D had higher HbA1c and BMIz values. Achieving optimal glycemic control and preventing obesity should be emphasized in pediatric diabetes care.Yun Jeong LeeSooyoung YooSoyoung YiSeok KimChunggak LeeJihoon ChoSoyeon AhnSunkyu ChoiHee HwangYoung Ah LeeChoong Ho ShinHyung-Jin YoonKwangsoo KimEunhye SongJin Ho ChoiHan Wook YooYoung-Hak KimJi Seon OhEun-Ae KangGa Kyoung BaekJae Hyun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Jeong Lee Sooyoung Yoo Soyoung Yi Seok Kim Chunggak Lee Jihoon Cho Soyeon Ahn Sunkyu Choi Hee Hwang Young Ah Lee Choong Ho Shin Hyung-Jin Yoon Kwangsoo Kim Eunhye Song Jin Ho Choi Han Wook Yoo Young-Hak Kim Ji Seon Oh Eun-Ae Kang Ga Kyoung Baek Jae Hyun Kim Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
description	Abstract We evaluated trajectories of glycated hemoglobin (HbA1c) levels and body mass index z-scores (BMIz) for 5 years after diagnosis among Korean children and adolescents with type 1 diabetes (T1D) or type 2 diabetes (T2D) using the common data model. From the de-identified database of three hospitals, 889 patients < 15 years of age diagnosed with T1D or T2D (393 boys, 664 T1D patients) were enrolled. Diagnosis was defined as first exposure to antidiabetic drug at each center. Compared with T2D patients, T1D patients had lower BMIz at diagnosis (− 0.4 ± 1.2 vs. 1.5 ± 1.4, p < 0.001) and 3 months (− 0.1 ± 1.0 vs. 1.5 ± 1.5, p < 0.001), and higher HbA1c levels at diagnosis (10.0 ± 2.6% vs. 9.5 ± 2.7%, p < 0.01). After 3 months, HbA1c levels reached a nadir of 7.6% and 6.5% in T1D and T2D patients, respectively, followed by progressive increases; only 10.4% of T1D and 29.7% of T2D patients achieved the recommended HbA1c target (< 7.0%) at 60 months. T1D patients showed consistent increases in BMIz; T2D patients showed no significant change in BMIz during follow-up. Peri-pubertal girls with T1D had higher HbA1c and BMIz values. Achieving optimal glycemic control and preventing obesity should be emphasized in pediatric diabetes care.
format	article
author	Yun Jeong Lee Sooyoung Yoo Soyoung Yi Seok Kim Chunggak Lee Jihoon Cho Soyeon Ahn Sunkyu Choi Hee Hwang Young Ah Lee Choong Ho Shin Hyung-Jin Yoon Kwangsoo Kim Eunhye Song Jin Ho Choi Han Wook Yoo Young-Hak Kim Ji Seon Oh Eun-Ae Kang Ga Kyoung Baek Jae Hyun Kim
author_facet	Yun Jeong Lee Sooyoung Yoo Soyoung Yi Seok Kim Chunggak Lee Jihoon Cho Soyeon Ahn Sunkyu Choi Hee Hwang Young Ah Lee Choong Ho Shin Hyung-Jin Yoon Kwangsoo Kim Eunhye Song Jin Ho Choi Han Wook Yoo Young-Hak Kim Ji Seon Oh Eun-Ae Kang Ga Kyoung Baek Jae Hyun Kim
author_sort	Yun Jeong Lee
title	Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
title_short	Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
title_full	Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
title_fullStr	Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
title_full_unstemmed	Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
title_sort	trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04f08118a6e5489fbb7a79e79f702eb2
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Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model

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