Capture Hi-C identifies putative target genes at 33 breast cancer risk loci

Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providing evidence of mechanisms that may influence the p...

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Autores principales:	Joseph S. Baxter, Olivia C. Leavy, Nicola H. Dryden, Sarah Maguire, Nichola Johnson, Vita Fedele, Nikiana Simigdala, Lesley-Ann Martin, Simon Andrews, Steven W. Wingett, Ioannis Assiotis, Kerry Fenwick, Ritika Chauhan, Alistair G. Rust, Nick Orr, Frank Dudbridge, Syed Haider, Olivia Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04f38edcab7d46faa2e61354e4ef0a11
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spelling	oai:doaj.org-article:04f38edcab7d46faa2e61354e4ef0a112021-12-02T17:32:32ZCapture Hi-C identifies putative target genes at 33 breast cancer risk loci10.1038/s41467-018-03411-92041-1723https://doaj.org/article/04f38edcab7d46faa2e61354e4ef0a112018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03411-9https://doaj.org/toc/2041-1723Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providing evidence of mechanisms that may influence the prognosis and risk of breast cancer.Joseph S. BaxterOlivia C. LeavyNicola H. DrydenSarah MaguireNichola JohnsonVita FedeleNikiana SimigdalaLesley-Ann MartinSimon AndrewsSteven W. WingettIoannis AssiotisKerry FenwickRitika ChauhanAlistair G. RustNick OrrFrank DudbridgeSyed HaiderOlivia FletcherNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph S. Baxter Olivia C. Leavy Nicola H. Dryden Sarah Maguire Nichola Johnson Vita Fedele Nikiana Simigdala Lesley-Ann Martin Simon Andrews Steven W. Wingett Ioannis Assiotis Kerry Fenwick Ritika Chauhan Alistair G. Rust Nick Orr Frank Dudbridge Syed Haider Olivia Fletcher Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
description	Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providing evidence of mechanisms that may influence the prognosis and risk of breast cancer.
format	article
author	Joseph S. Baxter Olivia C. Leavy Nicola H. Dryden Sarah Maguire Nichola Johnson Vita Fedele Nikiana Simigdala Lesley-Ann Martin Simon Andrews Steven W. Wingett Ioannis Assiotis Kerry Fenwick Ritika Chauhan Alistair G. Rust Nick Orr Frank Dudbridge Syed Haider Olivia Fletcher
author_facet	Joseph S. Baxter Olivia C. Leavy Nicola H. Dryden Sarah Maguire Nichola Johnson Vita Fedele Nikiana Simigdala Lesley-Ann Martin Simon Andrews Steven W. Wingett Ioannis Assiotis Kerry Fenwick Ritika Chauhan Alistair G. Rust Nick Orr Frank Dudbridge Syed Haider Olivia Fletcher
author_sort	Joseph S. Baxter
title	Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
title_short	Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
title_full	Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
title_fullStr	Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
title_full_unstemmed	Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
title_sort	capture hi-c identifies putative target genes at 33 breast cancer risk loci
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/04f38edcab7d46faa2e61354e4ef0a11
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Capture Hi-C identifies putative target genes at 33 breast cancer risk loci

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