Tau is required for the function of extrasynaptic NMDA receptors

Abstract Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent excitotoxicity. Of note, NMDA receptors ca...

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Autores principales:	Noemí Pallas-Bazarra, Jonathan Draffin, Raquel Cuadros, José Antonio Esteban, Jesús Avila
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04fb84d008734a7297c19f3d82650bb8
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spelling	oai:doaj.org-article:04fb84d008734a7297c19f3d82650bb82021-12-02T15:10:03ZTau is required for the function of extrasynaptic NMDA receptors10.1038/s41598-019-45547-82045-2322https://doaj.org/article/04fb84d008734a7297c19f3d82650bb82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45547-8https://doaj.org/toc/2045-2322Abstract Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent excitotoxicity. Of note, NMDA receptors can also be found outside synapses in the plasma membrane, and activation of extrasynaptic NMDA receptors has been shown to be more linked to excitotoxicity than the activation of synaptic ones. Little is known about the role of Tau in the activity of extrasynaptic NMDA receptors. Thus, we have used a Tau knockout mouse model (Tau−/− mice) to analyze the consequences of Tau absence in extrasynaptic NMDA receptor activity. We demonstrate that absence of Tau leads to a decrease in functional extrasynaptic NMDA receptors in the hippocampus. We propose that this impairment in extrasynaptic NMDA receptor activity may contribute to the well-known neuroprotective effect associated with Tau deficiency under pathological conditions.Noemí Pallas-BazarraJonathan DraffinRaquel CuadrosJosé Antonio EstebanJesús AvilaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noemí Pallas-Bazarra Jonathan Draffin Raquel Cuadros José Antonio Esteban Jesús Avila Tau is required for the function of extrasynaptic NMDA receptors
description	Abstract Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent excitotoxicity. Of note, NMDA receptors can also be found outside synapses in the plasma membrane, and activation of extrasynaptic NMDA receptors has been shown to be more linked to excitotoxicity than the activation of synaptic ones. Little is known about the role of Tau in the activity of extrasynaptic NMDA receptors. Thus, we have used a Tau knockout mouse model (Tau−/− mice) to analyze the consequences of Tau absence in extrasynaptic NMDA receptor activity. We demonstrate that absence of Tau leads to a decrease in functional extrasynaptic NMDA receptors in the hippocampus. We propose that this impairment in extrasynaptic NMDA receptor activity may contribute to the well-known neuroprotective effect associated with Tau deficiency under pathological conditions.
format	article
author	Noemí Pallas-Bazarra Jonathan Draffin Raquel Cuadros José Antonio Esteban Jesús Avila
author_facet	Noemí Pallas-Bazarra Jonathan Draffin Raquel Cuadros José Antonio Esteban Jesús Avila
author_sort	Noemí Pallas-Bazarra
title	Tau is required for the function of extrasynaptic NMDA receptors
title_short	Tau is required for the function of extrasynaptic NMDA receptors
title_full	Tau is required for the function of extrasynaptic NMDA receptors
title_fullStr	Tau is required for the function of extrasynaptic NMDA receptors
title_full_unstemmed	Tau is required for the function of extrasynaptic NMDA receptors
title_sort	tau is required for the function of extrasynaptic nmda receptors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/04fb84d008734a7297c19f3d82650bb8
work_keys_str_mv	AT noemipallasbazarra tauisrequiredforthefunctionofextrasynapticnmdareceptors AT jonathandraffin tauisrequiredforthefunctionofextrasynapticnmdareceptors AT raquelcuadros tauisrequiredforthefunctionofextrasynapticnmdareceptors AT joseantonioesteban tauisrequiredforthefunctionofextrasynapticnmdareceptors AT jesusavila tauisrequiredforthefunctionofextrasynapticnmdareceptors
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Tau is required for the function of extrasynaptic NMDA receptors

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