Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China

Yingjian Liang, Xiaobin Zheng, Meizhu Chen, Changli Tu, Cuiyan Tan, Yiying Huang, Zhenguo Wang, Jian Wu, Jing Liu Department of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of ChinaCorrespondence: Jing Liu; Xiaobin Zh...

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Autores principales:	Liang Y, Zheng X, Chen M, Tu C, Tan C, Huang Y, Wang Z, Wu J, Liu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	covid-19 negative detection clinical characteristic laboratory finding ct images features Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/04fe76062ead494e852a6d4dad02353f
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spelling	oai:doaj.org-article:04fe76062ead494e852a6d4dad02353f2021-11-11T18:22:26ZEpidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China1178-7074https://doaj.org/article/04fe76062ead494e852a6d4dad02353f2021-11-01T00:00:00Zhttps://www.dovepress.com/epidemiological-clinical-laboratorial-and-ct-imaging-features-of-hospi-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Yingjian Liang, Xiaobin Zheng, Meizhu Chen, Changli Tu, Cuiyan Tan, Yiying Huang, Zhenguo Wang, Jian Wu, Jing Liu Department of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of ChinaCorrespondence: Jing Liu; Xiaobin ZhengDepartment of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, 52 East Meihua Road, Zhuhai City, 519000, People’s Republic of ChinaTel/Fax +867562528733Email liujing25@mail.sysu.edu.cn; zhxbin@mail.sysu.edu.cnPurpose: The main objective of this study was to decipher the general epidemiology, clinical characteristic, laboratory finding and chest computed tomography (CT) imaging features of the novel coronavirus disease (COVID-19) patients whose initial detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)is negative.Methods: Nearly 100 confirmed cases admitted to The Fifth Affiliated Hospital of Sun Yat-sen University from 18th January to 26th February, 2020, were screened. Clinical records, laboratory results and CT images were reviewed for nine COVID-19 patients with initially negative RT-PCR detection.Results: Fever and cough were common, and one patient merely present gastrointestinal symptoms. Increasing CRP and decreasing ALB were showed in nearly half of the patients among negative detection and return to normal level after real time polymerase chain reaction (RT-PCR) results converted from positive to negative. Left lower lobe was affected nearly in all the patients. A patient received oxygen support timely according his high Mulbsta score.Conclusion: Our study elucidated on the clinical features of hospitalized patients with initially negative detection of SARS-CoV nucleic acid. Patient merely with symptoms associated with digestive system should be screened for COVID-19. CT scan and repeated RT-PCR are two powerful diagnostic tools. Mulbsta score assessing in the early stage enhances the confidence of severity evaluation in physician.Keywords: COVID-19, negative detection, clinical characteristic, laboratory finding, CT images featuresLiang YZheng XChen MTu CTan CHuang YWang ZWu JLiu JDove Medical Pressarticlecovid-19negative detectionclinical characteristiclaboratory findingct images featuresMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8039-8046 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 negative detection clinical characteristic laboratory finding ct images features Medicine (General) R5-920
spellingShingle	covid-19 negative detection clinical characteristic laboratory finding ct images features Medicine (General) R5-920 Liang Y Zheng X Chen M Tu C Tan C Huang Y Wang Z Wu J Liu J Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
description	Yingjian Liang, Xiaobin Zheng, Meizhu Chen, Changli Tu, Cuiyan Tan, Yiying Huang, Zhenguo Wang, Jian Wu, Jing Liu Department of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of ChinaCorrespondence: Jing Liu; Xiaobin ZhengDepartment of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, 52 East Meihua Road, Zhuhai City, 519000, People’s Republic of ChinaTel/Fax +867562528733Email liujing25@mail.sysu.edu.cn; zhxbin@mail.sysu.edu.cnPurpose: The main objective of this study was to decipher the general epidemiology, clinical characteristic, laboratory finding and chest computed tomography (CT) imaging features of the novel coronavirus disease (COVID-19) patients whose initial detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)is negative.Methods: Nearly 100 confirmed cases admitted to The Fifth Affiliated Hospital of Sun Yat-sen University from 18th January to 26th February, 2020, were screened. Clinical records, laboratory results and CT images were reviewed for nine COVID-19 patients with initially negative RT-PCR detection.Results: Fever and cough were common, and one patient merely present gastrointestinal symptoms. Increasing CRP and decreasing ALB were showed in nearly half of the patients among negative detection and return to normal level after real time polymerase chain reaction (RT-PCR) results converted from positive to negative. Left lower lobe was affected nearly in all the patients. A patient received oxygen support timely according his high Mulbsta score.Conclusion: Our study elucidated on the clinical features of hospitalized patients with initially negative detection of SARS-CoV nucleic acid. Patient merely with symptoms associated with digestive system should be screened for COVID-19. CT scan and repeated RT-PCR are two powerful diagnostic tools. Mulbsta score assessing in the early stage enhances the confidence of severity evaluation in physician.Keywords: COVID-19, negative detection, clinical characteristic, laboratory finding, CT images features
format	article
author	Liang Y Zheng X Chen M Tu C Tan C Huang Y Wang Z Wu J Liu J
author_facet	Liang Y Zheng X Chen M Tu C Tan C Huang Y Wang Z Wu J Liu J
author_sort	Liang Y
title	Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_short	Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_full	Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_fullStr	Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_full_unstemmed	Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_sort	epidemiological, clinical, laboratorial and ct imaging features of hospitalized patients with initially negative detection of sars-cov-2 in china
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/04fe76062ead494e852a6d4dad02353f
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Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China

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