Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study

Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical featu...

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Autores principales:	Leonardo Peterson dos Santos, Rafaela Cavalheiro do Espírito Santo, Émerson Pena, Lucas Denardi Dória, Vanessa Hax, Claiton Viegas Brenol, Odirlei André Monticielo, Rafael Mendonça da Silva Chakr, Ricardo Machado Xavier
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	rheumatoid arthritis muscle mass ultrasound muscle strength functionality sarcopenia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/050012d8e3ea4a98a862425c84d95eff
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spelling	oai:doaj.org-article:050012d8e3ea4a98a862425c84d95eff2021-11-25T17:20:44ZMorphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study10.3390/diagnostics111120142075-4418https://doaj.org/article/050012d8e3ea4a98a862425c84d95eff2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2014https://doaj.org/toc/2075-4418Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women (≥18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 ± 9.46 years; DAS28: 3.08 ± 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, <i>p</i> < 0.001; VI, <i>p</i> = 0.013; VL, <i>p</i> = 0.002) and disease duration (RF, <i>p</i> < 0.001; VI, <i>p</i> = 0.005; VL, <i>p</i> = 0.001), and were positively associated with handgrip strength (RF, <i>p</i> = 0.015; VI, <i>p</i> = 0.022; VL, <i>p</i> = 0.013). In addition, decreased muscle thickness in VI (<i>p</i> = 0.035) and a smaller pennation angle in RF (<i>p</i> = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle.Leonardo Peterson dos SantosRafaela Cavalheiro do Espírito SantoÉmerson PenaLucas Denardi DóriaVanessa HaxClaiton Viegas BrenolOdirlei André MonticieloRafael Mendonça da Silva ChakrRicardo Machado XavierMDPI AGarticlerheumatoid arthritismuscle massultrasoundmuscle strengthfunctionalitysarcopeniaMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2014, p 2014 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis muscle mass ultrasound muscle strength functionality sarcopenia Medicine (General) R5-920
spellingShingle	rheumatoid arthritis muscle mass ultrasound muscle strength functionality sarcopenia Medicine (General) R5-920 Leonardo Peterson dos Santos Rafaela Cavalheiro do Espírito Santo Émerson Pena Lucas Denardi Dória Vanessa Hax Claiton Viegas Brenol Odirlei André Monticielo Rafael Mendonça da Silva Chakr Ricardo Machado Xavier Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
description	Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women (≥18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 ± 9.46 years; DAS28: 3.08 ± 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, <i>p</i> < 0.001; VI, <i>p</i> = 0.013; VL, <i>p</i> = 0.002) and disease duration (RF, <i>p</i> < 0.001; VI, <i>p</i> = 0.005; VL, <i>p</i> = 0.001), and were positively associated with handgrip strength (RF, <i>p</i> = 0.015; VI, <i>p</i> = 0.022; VL, <i>p</i> = 0.013). In addition, decreased muscle thickness in VI (<i>p</i> = 0.035) and a smaller pennation angle in RF (<i>p</i> = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle.
format	article
author	Leonardo Peterson dos Santos Rafaela Cavalheiro do Espírito Santo Émerson Pena Lucas Denardi Dória Vanessa Hax Claiton Viegas Brenol Odirlei André Monticielo Rafael Mendonça da Silva Chakr Ricardo Machado Xavier
author_facet	Leonardo Peterson dos Santos Rafaela Cavalheiro do Espírito Santo Émerson Pena Lucas Denardi Dória Vanessa Hax Claiton Viegas Brenol Odirlei André Monticielo Rafael Mendonça da Silva Chakr Ricardo Machado Xavier
author_sort	Leonardo Peterson dos Santos
title	Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
title_short	Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
title_full	Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
title_fullStr	Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
title_full_unstemmed	Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study
title_sort	morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis: a cross-sectional study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/050012d8e3ea4a98a862425c84d95eff
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Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study

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