Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence

Abstract Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step t...

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Autores principales:	Jun-Ya Kaimori, Yoshitaka Isaka, Masaki Hatanaka, Satoko Yamamoto, Naotsugu Ichimaru, Akihiko Fujikawa, Hiroshi Shibata, Akira Fujimori, Sosuke Miyoshi, Takashi Yokawa, Kagayaki Kuroda, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0500d07c3e9642eba50eccfc919de3e0
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spelling	oai:doaj.org-article:0500d07c3e9642eba50eccfc919de3e02021-12-02T11:41:01ZVisualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence10.1038/s41598-017-06111-42045-2322https://doaj.org/article/0500d07c3e9642eba50eccfc919de3e02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06111-4https://doaj.org/toc/2045-2322Abstract Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a special kidney attachment was developed for long-term stabilization. The changes in renal temperature and blood flow during measurement were minimal, suggesting the feasibility of this method. At 38 weeks of age, RF had aggressively accumulated in the outer stripe (OS) of the outer medulla. FA maps showed that this method was successful in visualizing and evaluating fibrosis in the OS of the SHR/ND rat kidney (r = 0.7697, P = 0.0126). Interestingly, in the FA color maps, the directions of water molecule diffusion in RF were random, but distinct from conventional water diffusion in brain neuron fibers. These findings indicate that DTI MRI may be able to evaluate RF in CKD by DN.Jun-Ya KaimoriYoshitaka IsakaMasaki HatanakaSatoko YamamotoNaotsugu IchimaruAkihiko FujikawaHiroshi ShibataAkira FujimoriSosuke MiyoshiTakashi YokawaKagayaki KurodaToshiki MoriyamaHiromi RakugiShiro TakaharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun-Ya Kaimori Yoshitaka Isaka Masaki Hatanaka Satoko Yamamoto Naotsugu Ichimaru Akihiko Fujikawa Hiroshi Shibata Akira Fujimori Sosuke Miyoshi Takashi Yokawa Kagayaki Kuroda Toshiki Moriyama Hiromi Rakugi Shiro Takahara Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
description	Abstract Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a special kidney attachment was developed for long-term stabilization. The changes in renal temperature and blood flow during measurement were minimal, suggesting the feasibility of this method. At 38 weeks of age, RF had aggressively accumulated in the outer stripe (OS) of the outer medulla. FA maps showed that this method was successful in visualizing and evaluating fibrosis in the OS of the SHR/ND rat kidney (r = 0.7697, P = 0.0126). Interestingly, in the FA color maps, the directions of water molecule diffusion in RF were random, but distinct from conventional water diffusion in brain neuron fibers. These findings indicate that DTI MRI may be able to evaluate RF in CKD by DN.
format	article
author	Jun-Ya Kaimori Yoshitaka Isaka Masaki Hatanaka Satoko Yamamoto Naotsugu Ichimaru Akihiko Fujikawa Hiroshi Shibata Akira Fujimori Sosuke Miyoshi Takashi Yokawa Kagayaki Kuroda Toshiki Moriyama Hiromi Rakugi Shiro Takahara
author_facet	Jun-Ya Kaimori Yoshitaka Isaka Masaki Hatanaka Satoko Yamamoto Naotsugu Ichimaru Akihiko Fujikawa Hiroshi Shibata Akira Fujimori Sosuke Miyoshi Takashi Yokawa Kagayaki Kuroda Toshiki Moriyama Hiromi Rakugi Shiro Takahara
author_sort	Jun-Ya Kaimori
title	Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
title_short	Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
title_full	Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
title_fullStr	Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
title_full_unstemmed	Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
title_sort	visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging mri with spin-echo sequence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0500d07c3e9642eba50eccfc919de3e0
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Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence

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