Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor

Abstract Cryptochromes (CRY) have been proposed as putative magnetoreceptors in vertebrates. Localisation of CRY1 in the UV cones in the retinas of birds suggested that it could be the candidate magnetoreceptor. However, recent findings argue against this possibility. CRY1 is a type II cryptochrome,...

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Autores principales:	Atticus Pinzon-Rodriguez, Rachel Muheim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/050136fb3d83492a9ec7146a960de2fb
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spelling	oai:doaj.org-article:050136fb3d83492a9ec7146a960de2fb2021-12-02T17:40:49ZCryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor10.1038/s41598-021-92056-82045-2322https://doaj.org/article/050136fb3d83492a9ec7146a960de2fb2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92056-8https://doaj.org/toc/2045-2322Abstract Cryptochromes (CRY) have been proposed as putative magnetoreceptors in vertebrates. Localisation of CRY1 in the UV cones in the retinas of birds suggested that it could be the candidate magnetoreceptor. However, recent findings argue against this possibility. CRY1 is a type II cryptochrome, a subtype of cryptochromes that may not be inherently photosensitive, and it exhibits a clear circadian expression in the retinas of birds. Here, we reassessed the localisation and distribution of CRY1 in the retina of the zebra finch. Zebra finches have a light-dependent magnetic compass based on a radical-pair mechanism, similar to migratory birds. We found that CRY1 colocalised with the UV/V opsin (SWS1) in the outer segments of UV cones, but restricted to the tip of the segments. CRY1 was found in all UV cones across the entire retina, with the highest densities near the fovea. Pre-exposure of birds to different wavelengths of light did not result in any difference in CRY1 detection, suggesting that CRY1 did not undergo any detectable functional changes as result of light activation. Considering that CRY1 is likely not involved in magnetoreception, our findings open the possibility for an involvement in different, yet undetermined functions in the avian UV/V cones.Atticus Pinzon-RodriguezRachel MuheimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atticus Pinzon-Rodriguez Rachel Muheim Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
description	Abstract Cryptochromes (CRY) have been proposed as putative magnetoreceptors in vertebrates. Localisation of CRY1 in the UV cones in the retinas of birds suggested that it could be the candidate magnetoreceptor. However, recent findings argue against this possibility. CRY1 is a type II cryptochrome, a subtype of cryptochromes that may not be inherently photosensitive, and it exhibits a clear circadian expression in the retinas of birds. Here, we reassessed the localisation and distribution of CRY1 in the retina of the zebra finch. Zebra finches have a light-dependent magnetic compass based on a radical-pair mechanism, similar to migratory birds. We found that CRY1 colocalised with the UV/V opsin (SWS1) in the outer segments of UV cones, but restricted to the tip of the segments. CRY1 was found in all UV cones across the entire retina, with the highest densities near the fovea. Pre-exposure of birds to different wavelengths of light did not result in any difference in CRY1 detection, suggesting that CRY1 did not undergo any detectable functional changes as result of light activation. Considering that CRY1 is likely not involved in magnetoreception, our findings open the possibility for an involvement in different, yet undetermined functions in the avian UV/V cones.
format	article
author	Atticus Pinzon-Rodriguez Rachel Muheim
author_facet	Atticus Pinzon-Rodriguez Rachel Muheim
author_sort	Atticus Pinzon-Rodriguez
title	Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
title_short	Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
title_full	Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
title_fullStr	Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
title_full_unstemmed	Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor
title_sort	cryptochrome expression in avian uv cones: revisiting the role of cry1 as magnetoreceptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/050136fb3d83492a9ec7146a960de2fb
work_keys_str_mv	AT atticuspinzonrodriguez cryptochromeexpressioninavianuvconesrevisitingtheroleofcry1asmagnetoreceptor AT rachelmuheim cryptochromeexpressioninavianuvconesrevisitingtheroleofcry1asmagnetoreceptor
_version_	1718379685366202368

Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor

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