Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

ABSTRACT Pattern recognition receptor (PRR) detection of pathogen-associated molecular patterns (PAMPs), such as viral RNA, drives innate immune responses against West Nile virus (WNV), an emerging neurotropic pathogen. Here we demonstrate that WNV PAMPs orchestrate endothelial responses to WNV via...

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Autores principales: Brian P. Daniels, David W. Holman, Lillian Cruz-Orengo, Harsha Jujjavarapu, Douglas M. Durrant, Robyn S. Klein
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/0504bb4e5fff48d389082eb68d4c1eed
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