TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions
Abstract The invasion ability of glioblastoma (GBM) causes tumor cells to infiltrate the surrounding brain parenchyma and leads to poor outcomes. Transient receptor potential vanilloid 4 (TRPV4) exhibits a remarkable role in cancer cell motility, but the contribution of TRPV4 to glioblastoma metasta...
Guardado en:
Autores principales: | Wei Yang, Peng-fei Wu, Jian-xing Ma, Mao-jun Liao, Lun-shan Xu, Liang Yi |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0504ec51c83a47389dc2d5bd205e65c0 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis
por: Xin Duan, et al.
Publicado: (2021) -
Optogenetic dissection of Rac1 and Cdc42 gradient shaping
por: S. de Beco, et al.
Publicado: (2018) -
Theoretical model for cellular shapes driven by protrusive and adhesive forces.
por: Doron Kabaso, et al.
Publicado: (2011) -
MicroRNA-29a suppresses the growth of human cervical cancer cells by targeting cell division cycle 42 (CDC42)
por: Fang Song, et al.
Publicado: (2021) -
Identification of TRPV4 as a novel target in invasiveness of colorectal cancer
por: Peng Zhang, et al.
Publicado: (2021)