MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating th...

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Autores principales: Marcel A. Dammert, Johannes Brägelmann, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, Hannah L. Tumbrink, Matthew R. Guthrie, Sebastian Klein, Abbie S. Ireland, Jeremy Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D. Jachimowicz, Elmar Wolf, Roman K. Thomas, John T. Poirier, Reinhard Büttner, Triparna Sen, Lauren A. Byers, H. Christian Reinhardt, Anthony Letai, Trudy G. Oliver, Martin L. Sos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/05063d53c99b4d6497e917f9551d71f7
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spelling oai:doaj.org-article:05063d53c99b4d6497e917f9551d71f72021-12-02T15:35:38ZMYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer10.1038/s41467-019-11371-x2041-1723https://doaj.org/article/05063d53c99b4d6497e917f9551d71f72019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11371-xhttps://doaj.org/toc/2041-1723The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.Marcel A. DammertJohannes BrägelmannRachelle R. OlsenStefanie BöhmNiloufar MonhaseryChristopher P. WhitneyMilind D. ChalishazarHannah L. TumbrinkMatthew R. GuthrieSebastian KleinAbbie S. IrelandJeremy RyanAnna SchmittAnnika MarxLuka OzretićRoberta CastiglioneCarina LorenzRon D. JachimowiczElmar WolfRoman K. ThomasJohn T. PoirierReinhard BüttnerTriparna SenLauren A. ByersH. Christian ReinhardtAnthony LetaiTrudy G. OliverMartin L. SosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marcel A. Dammert
Johannes Brägelmann
Rachelle R. Olsen
Stefanie Böhm
Niloufar Monhasery
Christopher P. Whitney
Milind D. Chalishazar
Hannah L. Tumbrink
Matthew R. Guthrie
Sebastian Klein
Abbie S. Ireland
Jeremy Ryan
Anna Schmitt
Annika Marx
Luka Ozretić
Roberta Castiglione
Carina Lorenz
Ron D. Jachimowicz
Elmar Wolf
Roman K. Thomas
John T. Poirier
Reinhard Büttner
Triparna Sen
Lauren A. Byers
H. Christian Reinhardt
Anthony Letai
Trudy G. Oliver
Martin L. Sos
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
description The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.
format article
author Marcel A. Dammert
Johannes Brägelmann
Rachelle R. Olsen
Stefanie Böhm
Niloufar Monhasery
Christopher P. Whitney
Milind D. Chalishazar
Hannah L. Tumbrink
Matthew R. Guthrie
Sebastian Klein
Abbie S. Ireland
Jeremy Ryan
Anna Schmitt
Annika Marx
Luka Ozretić
Roberta Castiglione
Carina Lorenz
Ron D. Jachimowicz
Elmar Wolf
Roman K. Thomas
John T. Poirier
Reinhard Büttner
Triparna Sen
Lauren A. Byers
H. Christian Reinhardt
Anthony Letai
Trudy G. Oliver
Martin L. Sos
author_facet Marcel A. Dammert
Johannes Brägelmann
Rachelle R. Olsen
Stefanie Böhm
Niloufar Monhasery
Christopher P. Whitney
Milind D. Chalishazar
Hannah L. Tumbrink
Matthew R. Guthrie
Sebastian Klein
Abbie S. Ireland
Jeremy Ryan
Anna Schmitt
Annika Marx
Luka Ozretić
Roberta Castiglione
Carina Lorenz
Ron D. Jachimowicz
Elmar Wolf
Roman K. Thomas
John T. Poirier
Reinhard Büttner
Triparna Sen
Lauren A. Byers
H. Christian Reinhardt
Anthony Letai
Trudy G. Oliver
Martin L. Sos
author_sort Marcel A. Dammert
title MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
title_short MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
title_full MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
title_fullStr MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
title_full_unstemmed MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
title_sort myc paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/05063d53c99b4d6497e917f9551d71f7
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