Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and N...

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Autores principales:	Jodie P. Goodridge, Benedikt Jacobs, Michelle L. Saetersmoen, Dennis Clement, Quirin Hammer, Trevor Clancy, Ellen Skarpen, Andreas Brech, Johannes Landskron, Christian Grimm, Aline Pfefferle, Leonardo Meza-Zepeda, Susanne Lorenz, Merete Thune Wiiger, William E. Louch, Eivind Heggernes Ask, Lisa L. Liu, Vincent Yi Sheng Oei, Una Kjällquist, Sten Linnarsson, Sandip Patel, Kjetil Taskén, Harald Stenmark, Karl-Johan Malmberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05087ace24334bc9a23a8959b77fbf46
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spelling	oai:doaj.org-article:05087ace24334bc9a23a8959b77fbf462021-12-02T14:39:21ZRemodeling of secretory lysosomes during education tunes functional potential in NK cells10.1038/s41467-019-08384-x2041-1723https://doaj.org/article/05087ace24334bc9a23a8959b77fbf462019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08384-xhttps://doaj.org/toc/2041-1723Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and NK cell activation.Jodie P. GoodridgeBenedikt JacobsMichelle L. SaetersmoenDennis ClementQuirin HammerTrevor ClancyEllen SkarpenAndreas BrechJohannes LandskronChristian GrimmAline PfefferleLeonardo Meza-ZepedaSusanne LorenzMerete Thune WiigerWilliam E. LouchEivind Heggernes AskLisa L. LiuVincent Yi Sheng OeiUna KjällquistSten LinnarssonSandip PatelKjetil TaskénHarald StenmarkKarl-Johan MalmbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jodie P. Goodridge Benedikt Jacobs Michelle L. Saetersmoen Dennis Clement Quirin Hammer Trevor Clancy Ellen Skarpen Andreas Brech Johannes Landskron Christian Grimm Aline Pfefferle Leonardo Meza-Zepeda Susanne Lorenz Merete Thune Wiiger William E. Louch Eivind Heggernes Ask Lisa L. Liu Vincent Yi Sheng Oei Una Kjällquist Sten Linnarsson Sandip Patel Kjetil Taskén Harald Stenmark Karl-Johan Malmberg Remodeling of secretory lysosomes during education tunes functional potential in NK cells
description	Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and NK cell activation.
format	article
author	Jodie P. Goodridge Benedikt Jacobs Michelle L. Saetersmoen Dennis Clement Quirin Hammer Trevor Clancy Ellen Skarpen Andreas Brech Johannes Landskron Christian Grimm Aline Pfefferle Leonardo Meza-Zepeda Susanne Lorenz Merete Thune Wiiger William E. Louch Eivind Heggernes Ask Lisa L. Liu Vincent Yi Sheng Oei Una Kjällquist Sten Linnarsson Sandip Patel Kjetil Taskén Harald Stenmark Karl-Johan Malmberg
author_facet	Jodie P. Goodridge Benedikt Jacobs Michelle L. Saetersmoen Dennis Clement Quirin Hammer Trevor Clancy Ellen Skarpen Andreas Brech Johannes Landskron Christian Grimm Aline Pfefferle Leonardo Meza-Zepeda Susanne Lorenz Merete Thune Wiiger William E. Louch Eivind Heggernes Ask Lisa L. Liu Vincent Yi Sheng Oei Una Kjällquist Sten Linnarsson Sandip Patel Kjetil Taskén Harald Stenmark Karl-Johan Malmberg
author_sort	Jodie P. Goodridge
title	Remodeling of secretory lysosomes during education tunes functional potential in NK cells
title_short	Remodeling of secretory lysosomes during education tunes functional potential in NK cells
title_full	Remodeling of secretory lysosomes during education tunes functional potential in NK cells
title_fullStr	Remodeling of secretory lysosomes during education tunes functional potential in NK cells
title_full_unstemmed	Remodeling of secretory lysosomes during education tunes functional potential in NK cells
title_sort	remodeling of secretory lysosomes during education tunes functional potential in nk cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/05087ace24334bc9a23a8959b77fbf46
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Remodeling of secretory lysosomes during education tunes functional potential in NK cells

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