The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation of the polyadenylation (polyA) signal-mediat...

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Autores principales: Wolfgang Nacken, André Schreiber, Dörthe Masemann, Stephan Ludwig
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Microbiology
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spelling oai:doaj.org-article:0509ccc9b9db4d26bb5326552b3296482021-11-03T21:52:35ZThe Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus2150-751110.1128/mBio.02196-21https://doaj.org/article/0509ccc9b9db4d26bb5326552b3296482021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02196-21https://doaj.org/toc/2150-7511 We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation of the polyadenylation (polyA) signal-mediated 3′ termination of host transcription.Wolfgang NackenAndré SchreiberDörthe MasemannStephan LudwigAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Wolfgang Nacken
André Schreiber
Dörthe Masemann
Stephan Ludwig
The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
description We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation of the polyadenylation (polyA) signal-mediated 3′ termination of host transcription.
format article
author Wolfgang Nacken
André Schreiber
Dörthe Masemann
Stephan Ludwig
author_facet Wolfgang Nacken
André Schreiber
Dörthe Masemann
Stephan Ludwig
author_sort Wolfgang Nacken
title The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
title_short The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
title_full The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
title_fullStr The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
title_full_unstemmed The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
title_sort effector domain of the influenza a virus nonstructural protein ns1 triggers host shutoff by mediating inhibition and global deregulation of host transcription when associated with specific structures in the nucleus
publisher American Society for Microbiology
publishDate 2021
url https://doaj.org/article/0509ccc9b9db4d26bb5326552b329648
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