New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles

Abstract This paper provides a rigorous analysis on the measurement of the permittivity of two-dimensional anisotropic biological tissues such as skeletal muscle using the four-electrode impedance technique. The state-of-the-art technique requires individual electrodes placed at the same depth in co...

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Autores principales:	H. Kwon, M. Guasch, J. A. Nagy, S. B. Rutkove, B. Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/050baa825e3f42209602abb3f965a733
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spelling	oai:doaj.org-article:050baa825e3f42209602abb3f965a7332021-12-02T15:09:28ZNew electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles10.1038/s41598-019-39277-02045-2322https://doaj.org/article/050baa825e3f42209602abb3f965a7332019-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-39277-0https://doaj.org/toc/2045-2322Abstract This paper provides a rigorous analysis on the measurement of the permittivity of two-dimensional anisotropic biological tissues such as skeletal muscle using the four-electrode impedance technique. The state-of-the-art technique requires individual electrodes placed at the same depth in contact with the anisotropic material, e.g. using monopolar needles. In this case, the minimum of measurements in different directions needed to estimate the complex permittivity and its anisotropy direction is 3, which translates into 12 monopolar needle insertions (i.e. 3 directions × 4 electrodes in each direction). Here, we extend our previous work and equip the reader with 8 new methods for multipolar needles, where 2 or more electrodes are spaced along the needle’s shaft in contact with the tissue at different depths. Using multipolar needles, the new methods presented reduce the number of needle insertions by a factor of 2 with respect to the available methods. We illustrate the methods with numerical simulations and new experiments on ex vivo ovine skeletal muscle (n = 3). Multi-frequency longitudinal and transverse permittivity data from 30 kHz to 1 MHz is made publicly available in the supplementary material. The methods presented here for multipolar needles bring closer the application of needle electrical impedance to patients with neuromuscular diseases.H. KwonM. GuaschJ. A. NagyS. B. RutkoveB. SanchezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q H. Kwon M. Guasch J. A. Nagy S. B. Rutkove B. Sanchez New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
description	Abstract This paper provides a rigorous analysis on the measurement of the permittivity of two-dimensional anisotropic biological tissues such as skeletal muscle using the four-electrode impedance technique. The state-of-the-art technique requires individual electrodes placed at the same depth in contact with the anisotropic material, e.g. using monopolar needles. In this case, the minimum of measurements in different directions needed to estimate the complex permittivity and its anisotropy direction is 3, which translates into 12 monopolar needle insertions (i.e. 3 directions × 4 electrodes in each direction). Here, we extend our previous work and equip the reader with 8 new methods for multipolar needles, where 2 or more electrodes are spaced along the needle’s shaft in contact with the tissue at different depths. Using multipolar needles, the new methods presented reduce the number of needle insertions by a factor of 2 with respect to the available methods. We illustrate the methods with numerical simulations and new experiments on ex vivo ovine skeletal muscle (n = 3). Multi-frequency longitudinal and transverse permittivity data from 30 kHz to 1 MHz is made publicly available in the supplementary material. The methods presented here for multipolar needles bring closer the application of needle electrical impedance to patients with neuromuscular diseases.
format	article
author	H. Kwon M. Guasch J. A. Nagy S. B. Rutkove B. Sanchez
author_facet	H. Kwon M. Guasch J. A. Nagy S. B. Rutkove B. Sanchez
author_sort	H. Kwon
title	New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
title_short	New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
title_full	New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
title_fullStr	New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
title_full_unstemmed	New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
title_sort	new electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/050baa825e3f42209602abb3f965a733
work_keys_str_mv	AT hkwon newelectricalimpedancemethodsfortheinsitumeasurementofthecomplexpermittivityofanisotropicskeletalmuscleusingmultipolarneedles AT mguasch newelectricalimpedancemethodsfortheinsitumeasurementofthecomplexpermittivityofanisotropicskeletalmuscleusingmultipolarneedles AT janagy newelectricalimpedancemethodsfortheinsitumeasurementofthecomplexpermittivityofanisotropicskeletalmuscleusingmultipolarneedles AT sbrutkove newelectricalimpedancemethodsfortheinsitumeasurementofthecomplexpermittivityofanisotropicskeletalmuscleusingmultipolarneedles AT bsanchez newelectricalimpedancemethodsfortheinsitumeasurementofthecomplexpermittivityofanisotropicskeletalmuscleusingmultipolarneedles
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New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles

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