FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC

Abstract Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression and role of FAM83H in 163 human HCCs and further investigated the relationship betwe...

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Autores principales:	Kyoung Min Kim, See-Hyoung Park, Jun Sang Bae, Sang Jae Noh, Guo-Zhong Tao, Jung Ryul Kim, Keun Sang Kwon, Ho Sung Park, Byung-Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Karl G. Sylvester, Kyu Yun Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/050d529ee0894445a5b4edb6407c10c4
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spelling	oai:doaj.org-article:050d529ee0894445a5b4edb6407c10c42021-12-02T12:30:18ZFAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC10.1038/s41598-017-03639-32045-2322https://doaj.org/article/050d529ee0894445a5b4edb6407c10c42017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03639-3https://doaj.org/toc/2045-2322Abstract Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression and role of FAM83H in 163 human HCCs and further investigated the relationship between FAM83H and oncogene MYC. The expression of FAM83H is elevated in liver cancer cells, and nuclear expression of FAM83H predicted shorter survival of HCC patients. In HLE and HepG2 HCC cells, knock-down of FAM83H inhibited proliferation and invasive activity of HCC cells. FAM83H induced expression of cyclin-D1, cyclin-E1, snail and MMP2 and inhibited the expression of P53 and P27. In hepatic tumor cells derived from Tet-O-MYC mice, the expression of mRNA and protein of FAM83H were dependent on MYC expression. Moreover, a chromatin immunoprecipitation assay demonstrated that MYC binds to the promotor of FAM83H and that MYC promotes the transcription of FAM83H, which was supported by the results of a dual-luciferase reporter assay. In conclusion, we present an oncogenic role of FAM83H in liver cancer, which is closely associated with the oncogene MYC. In addition, our results suggest FAM83H expression as a poor prognostic indicator of HCC patients.Kyoung Min KimSee-Hyoung ParkJun Sang BaeSang Jae NohGuo-Zhong TaoJung Ryul KimKeun Sang KwonHo Sung ParkByung-Hyun ParkHo LeeMyoung Ja ChungWoo Sung MoonKarl G. SylvesterKyu Yun JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyoung Min Kim See-Hyoung Park Jun Sang Bae Sang Jae Noh Guo-Zhong Tao Jung Ryul Kim Keun Sang Kwon Ho Sung Park Byung-Hyun Park Ho Lee Myoung Ja Chung Woo Sung Moon Karl G. Sylvester Kyu Yun Jang FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
description	Abstract Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression and role of FAM83H in 163 human HCCs and further investigated the relationship between FAM83H and oncogene MYC. The expression of FAM83H is elevated in liver cancer cells, and nuclear expression of FAM83H predicted shorter survival of HCC patients. In HLE and HepG2 HCC cells, knock-down of FAM83H inhibited proliferation and invasive activity of HCC cells. FAM83H induced expression of cyclin-D1, cyclin-E1, snail and MMP2 and inhibited the expression of P53 and P27. In hepatic tumor cells derived from Tet-O-MYC mice, the expression of mRNA and protein of FAM83H were dependent on MYC expression. Moreover, a chromatin immunoprecipitation assay demonstrated that MYC binds to the promotor of FAM83H and that MYC promotes the transcription of FAM83H, which was supported by the results of a dual-luciferase reporter assay. In conclusion, we present an oncogenic role of FAM83H in liver cancer, which is closely associated with the oncogene MYC. In addition, our results suggest FAM83H expression as a poor prognostic indicator of HCC patients.
format	article
author	Kyoung Min Kim See-Hyoung Park Jun Sang Bae Sang Jae Noh Guo-Zhong Tao Jung Ryul Kim Keun Sang Kwon Ho Sung Park Byung-Hyun Park Ho Lee Myoung Ja Chung Woo Sung Moon Karl G. Sylvester Kyu Yun Jang
author_facet	Kyoung Min Kim See-Hyoung Park Jun Sang Bae Sang Jae Noh Guo-Zhong Tao Jung Ryul Kim Keun Sang Kwon Ho Sung Park Byung-Hyun Park Ho Lee Myoung Ja Chung Woo Sung Moon Karl G. Sylvester Kyu Yun Jang
author_sort	Kyoung Min Kim
title	FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
title_short	FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
title_full	FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
title_fullStr	FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
title_full_unstemmed	FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
title_sort	fam83h is involved in the progression of hepatocellular carcinoma and is regulated by myc
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/050d529ee0894445a5b4edb6407c10c4
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FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC

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