Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Herein, an inflamed joint‐targeting delivery platform is developed based on platelet‐derived extracellular vesicles (PEVs) that are naturally occurring nanoparticles released by platelets,...

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Autores principales:	Qingle Ma, Jinyu Bai, Jialu Xu, Huaxing Dai, Qin Fan, Ziying Fei, Jiacheng Chu, Chenlu Yao, Haoliang Shi, Xiaozhong Zhou, Lin Bo, Chao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	immunosuppressive platelet-derived extracellular vesicles rheumatoid arthritis targeted drug deliveries Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/050fa21737684c2e9e56844140f4a689
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spelling	oai:doaj.org-article:050fa21737684c2e9e56844140f4a6892021-11-06T04:12:26ZReshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles2699-930710.1002/anbr.202100071https://doaj.org/article/050fa21737684c2e9e56844140f4a6892021-11-01T00:00:00Zhttps://doi.org/10.1002/anbr.202100071https://doaj.org/toc/2699-9307Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Herein, an inflamed joint‐targeting delivery platform is developed based on platelet‐derived extracellular vesicles (PEVs) that are naturally occurring nanoparticles released by platelets, loaded with berberine (BBR) for suppressing the progress of RA. It is found that PEVs could selectively target the inflamed arthritis site in RA mice. In addition, BBR‐loaded PEVs exert anti‐inflammatory effects by reshaping the inflammatory environment in affected joints. It is shown that intravenous injection of BBR‐loaded PEVs into RA mice can effectively reduce joint swelling and bone erosion and restore mobility compared with free drug therapy. This strategy can effectively enhance the efficacy of RA treatment with limited side effects.Qingle MaJinyu BaiJialu XuHuaxing DaiQin FanZiying FeiJiacheng ChuChenlu YaoHaoliang ShiXiaozhong ZhouLin BoChao WangWiley-VCHarticleimmunosuppressiveplatelet-derived extracellular vesiclesrheumatoid arthritistargeted drug deliveriesBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENAdvanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunosuppressive platelet-derived extracellular vesicles rheumatoid arthritis targeted drug deliveries Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	immunosuppressive platelet-derived extracellular vesicles rheumatoid arthritis targeted drug deliveries Biotechnology TP248.13-248.65 Medical technology R855-855.5 Qingle Ma Jinyu Bai Jialu Xu Huaxing Dai Qin Fan Ziying Fei Jiacheng Chu Chenlu Yao Haoliang Shi Xiaozhong Zhou Lin Bo Chao Wang Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
description	Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Herein, an inflamed joint‐targeting delivery platform is developed based on platelet‐derived extracellular vesicles (PEVs) that are naturally occurring nanoparticles released by platelets, loaded with berberine (BBR) for suppressing the progress of RA. It is found that PEVs could selectively target the inflamed arthritis site in RA mice. In addition, BBR‐loaded PEVs exert anti‐inflammatory effects by reshaping the inflammatory environment in affected joints. It is shown that intravenous injection of BBR‐loaded PEVs into RA mice can effectively reduce joint swelling and bone erosion and restore mobility compared with free drug therapy. This strategy can effectively enhance the efficacy of RA treatment with limited side effects.
format	article
author	Qingle Ma Jinyu Bai Jialu Xu Huaxing Dai Qin Fan Ziying Fei Jiacheng Chu Chenlu Yao Haoliang Shi Xiaozhong Zhou Lin Bo Chao Wang
author_facet	Qingle Ma Jinyu Bai Jialu Xu Huaxing Dai Qin Fan Ziying Fei Jiacheng Chu Chenlu Yao Haoliang Shi Xiaozhong Zhou Lin Bo Chao Wang
author_sort	Qingle Ma
title	Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
title_short	Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
title_full	Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
title_fullStr	Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
title_full_unstemmed	Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
title_sort	reshaping the inflammatory environment in rheumatoid arthritis joints by targeting delivery of berberine with platelet‐derived extracellular vesicles
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/050fa21737684c2e9e56844140f4a689
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Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles

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