Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity

In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Valentine Bordier, Fabienne Teysseire, Götz Schlotterbeck, Frank Senner, Christoph Beglinger, Anne Christin Meyer-Gerspach, Bettina K. Wölnerhanssen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	erythritol xylitol natural sweeteners glucose absorption 3-OMG obesity Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/05100986ffc048928a374b9576e50fa6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05100986ffc048928a374b9576e50fa6
record_format	dspace
spelling	oai:doaj.org-article:05100986ffc048928a374b9576e50fa62021-11-25T18:35:33ZEffect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity10.3390/nu131139502072-6643https://doaj.org/article/05100986ffc048928a374b9576e50fa62021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3950https://doaj.org/toc/2072-6643In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3-<i>Ortho</i>-methyl-glucose (3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentration was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol, or erythritol), nor the time-by-group interaction effects were significant (<i>p =</i> 0.829, <i>p =</i> 0.821, and <i>p =</i> 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity.Valentine BordierFabienne TeysseireGötz SchlotterbeckFrank SennerChristoph BeglingerAnne Christin Meyer-GerspachBettina K. WölnerhanssenMDPI AGarticleerythritolxylitolnatural sweetenersglucose absorption3-OMGobesityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3950, p 3950 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	erythritol xylitol natural sweeteners glucose absorption 3-OMG obesity Nutrition. Foods and food supply TX341-641
spellingShingle	erythritol xylitol natural sweeteners glucose absorption 3-OMG obesity Nutrition. Foods and food supply TX341-641 Valentine Bordier Fabienne Teysseire Götz Schlotterbeck Frank Senner Christoph Beglinger Anne Christin Meyer-Gerspach Bettina K. Wölnerhanssen Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
description	In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3-<i>Ortho</i>-methyl-glucose (3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentration was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol, or erythritol), nor the time-by-group interaction effects were significant (<i>p =</i> 0.829, <i>p =</i> 0.821, and <i>p =</i> 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity.
format	article
author	Valentine Bordier Fabienne Teysseire Götz Schlotterbeck Frank Senner Christoph Beglinger Anne Christin Meyer-Gerspach Bettina K. Wölnerhanssen
author_facet	Valentine Bordier Fabienne Teysseire Götz Schlotterbeck Frank Senner Christoph Beglinger Anne Christin Meyer-Gerspach Bettina K. Wölnerhanssen
author_sort	Valentine Bordier
title	Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
title_short	Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
title_full	Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
title_fullStr	Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
title_full_unstemmed	Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
title_sort	effect of a chronic intake of the natural sweeteners xylitol and erythritol on glucose absorption in humans with obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/05100986ffc048928a374b9576e50fa6
work_keys_str_mv	AT valentinebordier effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT fabienneteysseire effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT gotzschlotterbeck effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT franksenner effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT christophbeglinger effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT annechristinmeyergerspach effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity AT bettinakwolnerhanssen effectofachronicintakeofthenaturalsweetenersxylitolanderythritolonglucoseabsorptioninhumanswithobesity
_version_	1718410933804466176

Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity

Ejemplares similares