An Integrated Approach for Treatment of Acute Type A Aortic Dissection
<i>Background and objective:</i> We reviewed a single-institution experience to verify the impact of surgery during different time intervals on early and late results in the treatment of patients with type A acute aortic dissection (A-AAD). <i>Materials and Methods</i>: From...
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MDPI AG
2021
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oai:doaj.org-article:05100afd57784d339b9704c397d7ca192021-11-25T18:18:09ZAn Integrated Approach for Treatment of Acute Type A Aortic Dissection10.3390/medicina571111551648-91441010-660Xhttps://doaj.org/article/05100afd57784d339b9704c397d7ca192021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1155https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and objective:</i> We reviewed a single-institution experience to verify the impact of surgery during different time intervals on early and late results in the treatment of patients with type A acute aortic dissection (A-AAD). <i>Materials and Methods</i>: From 2004 to 2021, a total of 258 patients underwent repair of A-AAD; patients were equally distributed among three periods: 2004–2010 (Era 1, <i>n</i> = 90), 2011–2016 (Era 2, <i>n</i> = 87), and 2017–2021 (Era 3, <i>n</i> = 81). The primary end-point was to assess whether through the years changes in indications, surgical strategies and techniques and increasing experience have influenced early and late outcomes of A-AAD repair. <i>Results</i>: Axillary artery cannulation was almost routinely used in Eras 2 (86%) and 3 (91%) while one femoral artery was mainly cannulated in Era 1 (91%) (<i>p</i> < 0.01). Retrograde cerebral perfusion was predominantly used in Era 1 (60%) while antegrade cerebral perfusion was preferred in Eras 2 (94%,) and 3 (100%); (<i>p</i> < 0.01). There was a significant increase of arch replacement procedures from Era 1 (11%) to Eras 2 (33%) and 3 (48%) (<i>p</i> < 0.01). A frozen elephant trunk was mainly performed in Era 3. Hospital mortality was 13% in Era 1, 11% in Era 2, and 4% in Era 3 (<i>p</i> = 0.07). Actuarial survival at 3 years is 74%, in Era 1, 78% in Era 2, and 89% in Era 3 (<i>p</i> = 0.05). <i>Conclusions</i>: With increasing experience and a more aggressive approach, including total arch replacement, repair of A-AAD can be performed with low operative mortality in many patients. Patient care and treatment by a specific team organization allows a faster diagnosis and referral for surgery allowing to further improve early and late outcomes.Igor VendraminAndrea LechiancoleDaniela PianiSandro SpongaConcetta Di NoraDaniele MuserUberto BortolottiUgolino LiviMDPI AGarticleacute dissectionarch replacementFETMedicine (General)R5-920ENMedicina, Vol 57, Iss 1155, p 1155 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
acute dissection arch replacement FET Medicine (General) R5-920 |
| spellingShingle |
acute dissection arch replacement FET Medicine (General) R5-920 Igor Vendramin Andrea Lechiancole Daniela Piani Sandro Sponga Concetta Di Nora Daniele Muser Uberto Bortolotti Ugolino Livi An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| description |
<i>Background and objective:</i> We reviewed a single-institution experience to verify the impact of surgery during different time intervals on early and late results in the treatment of patients with type A acute aortic dissection (A-AAD). <i>Materials and Methods</i>: From 2004 to 2021, a total of 258 patients underwent repair of A-AAD; patients were equally distributed among three periods: 2004–2010 (Era 1, <i>n</i> = 90), 2011–2016 (Era 2, <i>n</i> = 87), and 2017–2021 (Era 3, <i>n</i> = 81). The primary end-point was to assess whether through the years changes in indications, surgical strategies and techniques and increasing experience have influenced early and late outcomes of A-AAD repair. <i>Results</i>: Axillary artery cannulation was almost routinely used in Eras 2 (86%) and 3 (91%) while one femoral artery was mainly cannulated in Era 1 (91%) (<i>p</i> < 0.01). Retrograde cerebral perfusion was predominantly used in Era 1 (60%) while antegrade cerebral perfusion was preferred in Eras 2 (94%,) and 3 (100%); (<i>p</i> < 0.01). There was a significant increase of arch replacement procedures from Era 1 (11%) to Eras 2 (33%) and 3 (48%) (<i>p</i> < 0.01). A frozen elephant trunk was mainly performed in Era 3. Hospital mortality was 13% in Era 1, 11% in Era 2, and 4% in Era 3 (<i>p</i> = 0.07). Actuarial survival at 3 years is 74%, in Era 1, 78% in Era 2, and 89% in Era 3 (<i>p</i> = 0.05). <i>Conclusions</i>: With increasing experience and a more aggressive approach, including total arch replacement, repair of A-AAD can be performed with low operative mortality in many patients. Patient care and treatment by a specific team organization allows a faster diagnosis and referral for surgery allowing to further improve early and late outcomes. |
| format |
article |
| author |
Igor Vendramin Andrea Lechiancole Daniela Piani Sandro Sponga Concetta Di Nora Daniele Muser Uberto Bortolotti Ugolino Livi |
| author_facet |
Igor Vendramin Andrea Lechiancole Daniela Piani Sandro Sponga Concetta Di Nora Daniele Muser Uberto Bortolotti Ugolino Livi |
| author_sort |
Igor Vendramin |
| title |
An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| title_short |
An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| title_full |
An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| title_fullStr |
An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| title_full_unstemmed |
An Integrated Approach for Treatment of Acute Type A Aortic Dissection |
| title_sort |
integrated approach for treatment of acute type a aortic dissection |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/05100afd57784d339b9704c397d7ca19 |
| work_keys_str_mv |
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