SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY

We searched for a possible target tissue in eye orbit for thyroid autoantibodies in endocrine ophthalmopathy (Graves’ disease), using correlation analysis method. We examined a group of 139 patients (278 eye orbits) with thyroid-associated ophthalmopathy associated with diffuse toxic goiter. Serolog...

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Autores principales:	V. G. Likhvantseva, M. S. Afanasiev, E. A. Rudenko, A. V. Karaulov, E. V. Korostelyova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	thyroid-associated ophthalmopathy graves’ disease thyroid antibodies tsh receptor thyroglobulin antibodies thyroid peroxidase antibody eye orbit exophthalmos Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0511af3a01fc4c2c8ed8ce045e336711
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spelling	oai:doaj.org-article:0511af3a01fc4c2c8ed8ce045e3367112021-11-18T08:03:46ZSEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY1563-06252313-741X10.15789/1563-0625-2017-5-557-566https://doaj.org/article/0511af3a01fc4c2c8ed8ce045e3367112017-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1357https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe searched for a possible target tissue in eye orbit for thyroid autoantibodies in endocrine ophthalmopathy (Graves’ disease), using correlation analysis method. We examined a group of 139 patients (278 eye orbits) with thyroid-associated ophthalmopathy associated with diffuse toxic goiter. Serological parameters (antibodies to thyroid-stimulating hormone receptor; thyroglobulin, thyroid peroxidase) were compared with instrumental diagnostic data (multi-layer CT, ultrasonography of eye orbit, and exophthalmometer), as well as clinical symptoms. Statistical correlation analysis enabled us to show different degrees of association between thyroid antibodies and clinical manifestations of Graves’ disease and eye orbit involvement. Especially, carriers of antibodies to TSH receptor and thyroglobulin (as compared to seronegative patients) exhibited higher exophthalmos scores (19.16±0.26 mm, p < 0.001, and 19.41±0.40 mm, p < 0.05, respectively), and with total muscle index (2.42±0.05, p < 0.01, and 2.42±0.08, respectively). Meanwhile, eyelids in carriers of antibodies to TSH receptor and thyroid peroxidase proved to be more swollen (p < 0.001, p < 0.05, respectively). Carriage of antibodies to thyroglobulin was associated with synchronous involvement of two structures of the eye orbit: extraocular muscles and retrobulbar tissue, which is reflected by increase in the average ntegral exophthalmos index within the group.V. G. LikhvantsevaM. S. AfanasievE. A. RudenkoA. V. KaraulovE. V. KorostelyovaSPb RAACIarticlethyroid-associated ophthalmopathygraves’ diseasethyroid antibodiestsh receptorthyroglobulin antibodiesthyroid peroxidase antibodyeye orbitexophthalmosImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 5, Pp 557-566 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	thyroid-associated ophthalmopathy graves’ disease thyroid antibodies tsh receptor thyroglobulin antibodies thyroid peroxidase antibody eye orbit exophthalmos Immunologic diseases. Allergy RC581-607
spellingShingle	thyroid-associated ophthalmopathy graves’ disease thyroid antibodies tsh receptor thyroglobulin antibodies thyroid peroxidase antibody eye orbit exophthalmos Immunologic diseases. Allergy RC581-607 V. G. Likhvantseva M. S. Afanasiev E. A. Rudenko A. V. Karaulov E. V. Korostelyova SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
description	We searched for a possible target tissue in eye orbit for thyroid autoantibodies in endocrine ophthalmopathy (Graves’ disease), using correlation analysis method. We examined a group of 139 patients (278 eye orbits) with thyroid-associated ophthalmopathy associated with diffuse toxic goiter. Serological parameters (antibodies to thyroid-stimulating hormone receptor; thyroglobulin, thyroid peroxidase) were compared with instrumental diagnostic data (multi-layer CT, ultrasonography of eye orbit, and exophthalmometer), as well as clinical symptoms. Statistical correlation analysis enabled us to show different degrees of association between thyroid antibodies and clinical manifestations of Graves’ disease and eye orbit involvement. Especially, carriers of antibodies to TSH receptor and thyroglobulin (as compared to seronegative patients) exhibited higher exophthalmos scores (19.16±0.26 mm, p < 0.001, and 19.41±0.40 mm, p < 0.05, respectively), and with total muscle index (2.42±0.05, p < 0.01, and 2.42±0.08, respectively). Meanwhile, eyelids in carriers of antibodies to TSH receptor and thyroid peroxidase proved to be more swollen (p < 0.001, p < 0.05, respectively). Carriage of antibodies to thyroglobulin was associated with synchronous involvement of two structures of the eye orbit: extraocular muscles and retrobulbar tissue, which is reflected by increase in the average ntegral exophthalmos index within the group.
format	article
author	V. G. Likhvantseva M. S. Afanasiev E. A. Rudenko A. V. Karaulov E. V. Korostelyova
author_facet	V. G. Likhvantseva M. S. Afanasiev E. A. Rudenko A. V. Karaulov E. V. Korostelyova
author_sort	V. G. Likhvantseva
title	SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
title_short	SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
title_full	SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
title_fullStr	SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
title_full_unstemmed	SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY
title_sort	search for target tissue in the eye orbit for autoimmune aggression of thyroid antibodies in endocrine ophthalmopathy
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/0511af3a01fc4c2c8ed8ce045e336711
work_keys_str_mv	AT vglikhvantseva searchfortargettissueintheeyeorbitforautoimmuneaggressionofthyroidantibodiesinendocrineophthalmopathy AT msafanasiev searchfortargettissueintheeyeorbitforautoimmuneaggressionofthyroidantibodiesinendocrineophthalmopathy AT earudenko searchfortargettissueintheeyeorbitforautoimmuneaggressionofthyroidantibodiesinendocrineophthalmopathy AT avkaraulov searchfortargettissueintheeyeorbitforautoimmuneaggressionofthyroidantibodiesinendocrineophthalmopathy AT evkorostelyova searchfortargettissueintheeyeorbitforautoimmuneaggressionofthyroidantibodiesinendocrineophthalmopathy
_version_	1718422394561888256

SEARCH FOR TARGET TISSUE IN THE EYE ORBIT FOR AUTOIMMUNE AGGRESSION OF THYROID ANTIBODIES IN ENDOCRINE OPHTHALMOPATHY

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