Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

Microsatellite-stable (MSS) colorectal cancer (CRC) has shown poor response to checkpoint blockade immunotherapy. Here, the authors show that the combination of oxaliplatin with anti-PDL1 mAb is specifically efficient in the treatment of MSS CRC.

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Autores principales:	Wantong Song, Limei Shen, Ying Wang, Qi Liu, Tyler J. Goodwin, Jingjing Li, Olekasandra Dorosheva, Tianzhou Liu, Rihe Liu, Leaf Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0515a6d971844b1e8f9a10f726dac7a6
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spelling	oai:doaj.org-article:0515a6d971844b1e8f9a10f726dac7a62021-12-02T16:49:33ZSynergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap10.1038/s41467-018-04605-x2041-1723https://doaj.org/article/0515a6d971844b1e8f9a10f726dac7a62018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04605-xhttps://doaj.org/toc/2041-1723Microsatellite-stable (MSS) colorectal cancer (CRC) has shown poor response to checkpoint blockade immunotherapy. Here, the authors show that the combination of oxaliplatin with anti-PDL1 mAb is specifically efficient in the treatment of MSS CRC.Wantong SongLimei ShenYing WangQi LiuTyler J. GoodwinJingjing LiOlekasandra DoroshevaTianzhou LiuRihe LiuLeaf HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wantong Song Limei Shen Ying Wang Qi Liu Tyler J. Goodwin Jingjing Li Olekasandra Dorosheva Tianzhou Liu Rihe Liu Leaf Huang Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
description	Microsatellite-stable (MSS) colorectal cancer (CRC) has shown poor response to checkpoint blockade immunotherapy. Here, the authors show that the combination of oxaliplatin with anti-PDL1 mAb is specifically efficient in the treatment of MSS CRC.
format	article
author	Wantong Song Limei Shen Ying Wang Qi Liu Tyler J. Goodwin Jingjing Li Olekasandra Dorosheva Tianzhou Liu Rihe Liu Leaf Huang
author_facet	Wantong Song Limei Shen Ying Wang Qi Liu Tyler J. Goodwin Jingjing Li Olekasandra Dorosheva Tianzhou Liu Rihe Liu Leaf Huang
author_sort	Wantong Song
title	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
title_short	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
title_full	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
title_fullStr	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
title_full_unstemmed	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
title_sort	synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed pd-l1 trap
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0515a6d971844b1e8f9a10f726dac7a6
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Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

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