Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity.
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Nature Portfolio
2019
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oai:doaj.org-article:051986d29ba44b0d9f2cf3bc9a46a0bb2021-12-02T17:01:45ZPodocyte GSK3 is an evolutionarily conserved critical regulator of kidney function10.1038/s41467-018-08235-12041-1723https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08235-1https://doaj.org/toc/2041-1723Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity.J. A. HurcombeP. HartleyA. C. LayL. NiJ. J. BedfordJ. P. LeaderS. SinghA. MurphyC. L. ScudamoreE. MarquezA. F. BarringtonV. PintoM. MarchettiL.-F. WongJ. UneyM. A. SaleemP. W. MathiesonS. PatelR. J. WalkerJ. R. WoodgettS. E. QuagginG. I. WelshR. J. M. CowardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q J. A. Hurcombe P. Hartley A. C. Lay L. Ni J. J. Bedford J. P. Leader S. Singh A. Murphy C. L. Scudamore E. Marquez A. F. Barrington V. Pinto M. Marchetti L.-F. Wong J. Uney M. A. Saleem P. W. Mathieson S. Patel R. J. Walker J. R. Woodgett S. E. Quaggin G. I. Welsh R. J. M. Coward Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| description |
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity. |
| format |
article |
| author |
J. A. Hurcombe P. Hartley A. C. Lay L. Ni J. J. Bedford J. P. Leader S. Singh A. Murphy C. L. Scudamore E. Marquez A. F. Barrington V. Pinto M. Marchetti L.-F. Wong J. Uney M. A. Saleem P. W. Mathieson S. Patel R. J. Walker J. R. Woodgett S. E. Quaggin G. I. Welsh R. J. M. Coward |
| author_facet |
J. A. Hurcombe P. Hartley A. C. Lay L. Ni J. J. Bedford J. P. Leader S. Singh A. Murphy C. L. Scudamore E. Marquez A. F. Barrington V. Pinto M. Marchetti L.-F. Wong J. Uney M. A. Saleem P. W. Mathieson S. Patel R. J. Walker J. R. Woodgett S. E. Quaggin G. I. Welsh R. J. M. Coward |
| author_sort |
J. A. Hurcombe |
| title |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| title_short |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| title_full |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| title_fullStr |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| title_full_unstemmed |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function |
| title_sort |
podocyte gsk3 is an evolutionarily conserved critical regulator of kidney function |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb |
| work_keys_str_mv |
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| _version_ |
1718382007718772736 |