SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

Abstract Insulin secretion from pancreatic ß cells is a multistep process that requires the coordination of exocytotic proteins that integrate diverse signals. These include signals derived from metabolic control of post-translational SUMOylation and depolarization-induced rises in intracellular Ca2...

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Autores principales: Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, Jocelyn E. Manning Fox, Kunimasa Suzuki, Nancy Smith, Gregory Plummer, Patrick E. MacDonald
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/051a727042634a409608aa2b2820abb6
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