The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in so doing is a negative regulator of non-canon...

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Autores principales:	Lan H. Chu, Mohanalaxmi Indramohan, Rojo A. Ratsimandresy, Anu Gangopadhyay, Emily P. Morris, Denise M. Monack, Andrea Dorfleutner, Christian Stehlik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/051c24abc08d472889c0b489dddc6f44
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spelling	oai:doaj.org-article:051c24abc08d472889c0b489dddc6f442021-12-02T17:32:45ZThe oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages10.1038/s41467-018-03409-32041-1723https://doaj.org/article/051c24abc08d472889c0b489dddc6f442018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03409-3https://doaj.org/toc/2041-1723Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in so doing is a negative regulator of non-canonical inflammasome activation in macrophages, but not in dendritic cells.Lan H. ChuMohanalaxmi IndramohanRojo A. RatsimandresyAnu GangopadhyayEmily P. MorrisDenise M. MonackAndrea DorfleutnerChristian StehlikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lan H. Chu Mohanalaxmi Indramohan Rojo A. Ratsimandresy Anu Gangopadhyay Emily P. Morris Denise M. Monack Andrea Dorfleutner Christian Stehlik The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
description	Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in so doing is a negative regulator of non-canonical inflammasome activation in macrophages, but not in dendritic cells.
format	article
author	Lan H. Chu Mohanalaxmi Indramohan Rojo A. Ratsimandresy Anu Gangopadhyay Emily P. Morris Denise M. Monack Andrea Dorfleutner Christian Stehlik
author_facet	Lan H. Chu Mohanalaxmi Indramohan Rojo A. Ratsimandresy Anu Gangopadhyay Emily P. Morris Denise M. Monack Andrea Dorfleutner Christian Stehlik
author_sort	Lan H. Chu
title	The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
title_short	The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
title_full	The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
title_fullStr	The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
title_full_unstemmed	The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
title_sort	oxidized phospholipid oxpapc protects from septic shock by targeting the non-canonical inflammasome in macrophages
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/051c24abc08d472889c0b489dddc6f44
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The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

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