Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine

In this work systematization (classification) of biochemical and physiological processes that cause disorders in the human body during the development of diabetes mellitus is carried out. The development of the disease is considered as the interaction and mutual reinforcement of two groups of parall...

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Autores principales:	Semen V. Nesterov, Lev S. Yaguzhinsky, Gennady I. Podoprigora, Yaroslav R. Nartsissov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	diabetes mellitus glycine microcirculation advanced glycosylation end products inflammation reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/0520b12109b0433089072c438fbb3006
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spelling	oai:doaj.org-article:0520b12109b0433089072c438fbb30062021-11-14T09:00:21ZAutocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine2072-03512072-037810.14341/DM9529https://doaj.org/article/0520b12109b0433089072c438fbb30062018-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9529https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378In this work systematization (classification) of biochemical and physiological processes that cause disorders in the human body during the development of diabetes mellitus is carried out. The development of the disease is considered as the interaction and mutual reinforcement of two groups of parallel processes. The first group has a molecular nature and it is associated with impairment of ROS-regulation system which includes NADPH oxidases, RAGE receptors, mitochondria, cellular peroxireductase system and the immune system. The second group has a pathophysiological nature and it is associated with impairment of microcirculation and liver metabolism. The analysis of diabetes biochemistry based on different published references yields a creation of a block diagram evaluating the disease development over time. Two types of autocatalytic processes were identified: autocatalysis in the cascade of biochemical reactions and "cross-section" catalysis, in which biochemical and pathophysiological processes reinforce each other. The developed model has shown the possibility of using pharmacologically active natural metabolite glycine as a medicine inhibiting the development of diabetes. Despite the fact that glycine is a substitute amino acid the drop in the glycine blood concentration occurs even in the early stages of diabetes development and can aggravate the disease. It is shown that glycine is a potential blocker of key autocatalytic cycles, including biochemical and pathophysiological processes. The analysis of the glycine action based on the developed model is in complete agreement with the results of clinical trials in which glycine has improved blood biochemistry of diabetic patients and thereby it prevents the development of diabetic complications.Semen V. NesterovLev S. YaguzhinskyGennady I. PodoprigoraYaroslav R. NartsissovEndocrinology Research Centrearticlediabetes mellitusglycinemicrocirculationadvanced glycosylation end productsinflammationreactive oxygen speciesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 4, Pp 283-292 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus glycine microcirculation advanced glycosylation end products inflammation reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus glycine microcirculation advanced glycosylation end products inflammation reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627 Semen V. Nesterov Lev S. Yaguzhinsky Gennady I. Podoprigora Yaroslav R. Nartsissov Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
description	In this work systematization (classification) of biochemical and physiological processes that cause disorders in the human body during the development of diabetes mellitus is carried out. The development of the disease is considered as the interaction and mutual reinforcement of two groups of parallel processes. The first group has a molecular nature and it is associated with impairment of ROS-regulation system which includes NADPH oxidases, RAGE receptors, mitochondria, cellular peroxireductase system and the immune system. The second group has a pathophysiological nature and it is associated with impairment of microcirculation and liver metabolism. The analysis of diabetes biochemistry based on different published references yields a creation of a block diagram evaluating the disease development over time. Two types of autocatalytic processes were identified: autocatalysis in the cascade of biochemical reactions and "cross-section" catalysis, in which biochemical and pathophysiological processes reinforce each other. The developed model has shown the possibility of using pharmacologically active natural metabolite glycine as a medicine inhibiting the development of diabetes. Despite the fact that glycine is a substitute amino acid the drop in the glycine blood concentration occurs even in the early stages of diabetes development and can aggravate the disease. It is shown that glycine is a potential blocker of key autocatalytic cycles, including biochemical and pathophysiological processes. The analysis of the glycine action based on the developed model is in complete agreement with the results of clinical trials in which glycine has improved blood biochemistry of diabetic patients and thereby it prevents the development of diabetic complications.
format	article
author	Semen V. Nesterov Lev S. Yaguzhinsky Gennady I. Podoprigora Yaroslav R. Nartsissov
author_facet	Semen V. Nesterov Lev S. Yaguzhinsky Gennady I. Podoprigora Yaroslav R. Nartsissov
author_sort	Semen V. Nesterov
title	Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
title_short	Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
title_full	Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
title_fullStr	Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
title_full_unstemmed	Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
title_sort	autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/0520b12109b0433089072c438fbb3006
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Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine

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