The role of inflammation and interleukin-1 in acute cerebrovascular disease

James Galea,1 David Brough21Manchester Academic Health Sciences Center, Brain Injury Research Group, Clinical Sciences Building, Salford Royal Foundation Trust, Salford, UK; 2Faculty of Life Sciences, University of Manchester, AV Hill Building, Manchester, UKAbstract: Acute cerebrovascular disease c...

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Autores principales:	Galea J, Brough D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0523485874ef4f4bb4e46a6338c4d1c3
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spelling	oai:doaj.org-article:0523485874ef4f4bb4e46a6338c4d1c32021-12-02T09:21:32ZThe role of inflammation and interleukin-1 in acute cerebrovascular disease1178-7031https://doaj.org/article/0523485874ef4f4bb4e46a6338c4d1c32013-08-01T00:00:00Zhttp://www.dovepress.com/the-role-of-inflammation-and-interleukin-1-in-acute-cerebrovascular-di-a14090https://doaj.org/toc/1178-7031James Galea,1 David Brough21Manchester Academic Health Sciences Center, Brain Injury Research Group, Clinical Sciences Building, Salford Royal Foundation Trust, Salford, UK; 2Faculty of Life Sciences, University of Manchester, AV Hill Building, Manchester, UKAbstract: Acute cerebrovascular disease can affect people at all stages of life, from neonates to the elderly, with devastating consequences. It is responsible for up to 10% of deaths worldwide, is a major cause of disability, and represents an area of real unmet clinical need. Acute cerebrovascular disease is multifactorial with many mechanisms contributing to a complex pathophysiology. One of the major processes worsening disease severity and outcome is inflammation. Pro-inflammatory cytokines of the interleukin (IL)-1 family are now known to drive damaging inflammatory processes in the brain. The aim of this review is to discuss the recent literature describing the role of IL-1 in acute cerebrovascular disease and to provide an update on our current understanding of the mechanisms of IL-1 production. We also discuss the recent literature where the effects of IL-1 have been targeted in animal models, thus reviewing potential future strategies that may limit the devastating effects of acute cerebrovascular disease.Keywords: cerebral ischemia, stroke, inflammation, microglia, interleukin-1, caspase-1Galea JBrough DDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2013, Iss default, Pp 121-128 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Galea J Brough D The role of inflammation and interleukin-1 in acute cerebrovascular disease
description	James Galea,1 David Brough21Manchester Academic Health Sciences Center, Brain Injury Research Group, Clinical Sciences Building, Salford Royal Foundation Trust, Salford, UK; 2Faculty of Life Sciences, University of Manchester, AV Hill Building, Manchester, UKAbstract: Acute cerebrovascular disease can affect people at all stages of life, from neonates to the elderly, with devastating consequences. It is responsible for up to 10% of deaths worldwide, is a major cause of disability, and represents an area of real unmet clinical need. Acute cerebrovascular disease is multifactorial with many mechanisms contributing to a complex pathophysiology. One of the major processes worsening disease severity and outcome is inflammation. Pro-inflammatory cytokines of the interleukin (IL)-1 family are now known to drive damaging inflammatory processes in the brain. The aim of this review is to discuss the recent literature describing the role of IL-1 in acute cerebrovascular disease and to provide an update on our current understanding of the mechanisms of IL-1 production. We also discuss the recent literature where the effects of IL-1 have been targeted in animal models, thus reviewing potential future strategies that may limit the devastating effects of acute cerebrovascular disease.Keywords: cerebral ischemia, stroke, inflammation, microglia, interleukin-1, caspase-1
format	article
author	Galea J Brough D
author_facet	Galea J Brough D
author_sort	Galea J
title	The role of inflammation and interleukin-1 in acute cerebrovascular disease
title_short	The role of inflammation and interleukin-1 in acute cerebrovascular disease
title_full	The role of inflammation and interleukin-1 in acute cerebrovascular disease
title_fullStr	The role of inflammation and interleukin-1 in acute cerebrovascular disease
title_full_unstemmed	The role of inflammation and interleukin-1 in acute cerebrovascular disease
title_sort	role of inflammation and interleukin-1 in acute cerebrovascular disease
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/0523485874ef4f4bb4e46a6338c4d1c3
work_keys_str_mv	AT galeaj theroleofinflammationandinterleukin1inacutecerebrovasculardisease AT broughd theroleofinflammationandinterleukin1inacutecerebrovasculardisease AT galeaj roleofinflammationandinterleukin1inacutecerebrovasculardisease AT broughd roleofinflammationandinterleukin1inacutecerebrovasculardisease
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The role of inflammation and interleukin-1 in acute cerebrovascular disease

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