Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 de...

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Autores principales:	Urszula Cytlak, Anastasia Resteu, Delfien Bogaert, Hye Sun Kuehn, Thomas Altmann, Andrew Gennery, Graham Jackson, Attila Kumanovics, Karl V. Voelkerding, Seraina Prader, Melissa Dullaers, Janine Reichenbach, Harry Hill, Filomeen Haerynck, Sergio D. Rosenzweig, Matthew Collin, Venetia Bigley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/052768b869044a2d884f1ad1b5b273c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:052768b869044a2d884f1ad1b5b273c92021-12-02T17:33:16ZIkaros family zinc finger 1 regulates dendritic cell development and function in humans10.1038/s41467-018-02977-82041-1723https://doaj.org/article/052768b869044a2d884f1ad1b5b273c92018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02977-8https://doaj.org/toc/2041-1723IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 deficiency.Urszula CytlakAnastasia ResteuDelfien BogaertHye Sun KuehnThomas AltmannAndrew GenneryGraham JacksonAttila KumanovicsKarl V. VoelkerdingSeraina PraderMelissa DullaersJanine ReichenbachHarry HillFilomeen HaerynckSergio D. RosenzweigMatthew CollinVenetia BigleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Urszula Cytlak Anastasia Resteu Delfien Bogaert Hye Sun Kuehn Thomas Altmann Andrew Gennery Graham Jackson Attila Kumanovics Karl V. Voelkerding Seraina Prader Melissa Dullaers Janine Reichenbach Harry Hill Filomeen Haerynck Sergio D. Rosenzweig Matthew Collin Venetia Bigley Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
description	IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 deficiency.
format	article
author	Urszula Cytlak Anastasia Resteu Delfien Bogaert Hye Sun Kuehn Thomas Altmann Andrew Gennery Graham Jackson Attila Kumanovics Karl V. Voelkerding Seraina Prader Melissa Dullaers Janine Reichenbach Harry Hill Filomeen Haerynck Sergio D. Rosenzweig Matthew Collin Venetia Bigley
author_facet	Urszula Cytlak Anastasia Resteu Delfien Bogaert Hye Sun Kuehn Thomas Altmann Andrew Gennery Graham Jackson Attila Kumanovics Karl V. Voelkerding Seraina Prader Melissa Dullaers Janine Reichenbach Harry Hill Filomeen Haerynck Sergio D. Rosenzweig Matthew Collin Venetia Bigley
author_sort	Urszula Cytlak
title	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
title_short	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
title_full	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
title_fullStr	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
title_full_unstemmed	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
title_sort	ikaros family zinc finger 1 regulates dendritic cell development and function in humans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/052768b869044a2d884f1ad1b5b273c9
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Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

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