Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic natural pausing sites (NPSs).

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Autores principales:	Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal, Dana Branzei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05276fd617f0402ba03a03fa5c996f82
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spelling	oai:doaj.org-article:05276fd617f0402ba03a03fa5c996f822021-12-02T14:26:56ZSmc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites10.1038/s41467-021-22217-w2041-1723https://doaj.org/article/05276fd617f0402ba03a03fa5c996f822021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22217-whttps://doaj.org/toc/2041-1723Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic natural pausing sites (NPSs).Sumedha AgasheChinnu Rose JosephTeresa Anne Clarisse ReyesDemis MenolfiMichele GiannattasioAnja WaizeneggerBarnabas SzakalDana BranzeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumedha Agashe Chinnu Rose Joseph Teresa Anne Clarisse Reyes Demis Menolfi Michele Giannattasio Anja Waizenegger Barnabas Szakal Dana Branzei Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
description	Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic natural pausing sites (NPSs).
format	article
author	Sumedha Agashe Chinnu Rose Joseph Teresa Anne Clarisse Reyes Demis Menolfi Michele Giannattasio Anja Waizenegger Barnabas Szakal Dana Branzei
author_facet	Sumedha Agashe Chinnu Rose Joseph Teresa Anne Clarisse Reyes Demis Menolfi Michele Giannattasio Anja Waizenegger Barnabas Szakal Dana Branzei
author_sort	Sumedha Agashe
title	Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
title_short	Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
title_full	Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
title_fullStr	Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
title_full_unstemmed	Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
title_sort	smc5/6 functions with sgs1-top3-rmi1 to complete chromosome replication at natural pause sites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05276fd617f0402ba03a03fa5c996f82
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Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

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