Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

Denghui Liu,1,* Chongru He,2,* Zhongtang Liu,2 Weidong Xu2 1Department of Orthopedics, the 113 Military Hospital, Ningbo, 2Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed eq...

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Autores principales:	Liu D, He C, Liu Z, Xu W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nanotubular anodized titanium gentamicin titanium implant infection antibiotic Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/052aeef4e9a44e1ca9244adb198facd3
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spelling	oai:doaj.org-article:052aeef4e9a44e1ca9244adb198facd32021-12-02T01:19:48ZGentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits1178-2013https://doaj.org/article/052aeef4e9a44e1ca9244adb198facd32017-07-01T00:00:00Zhttps://www.dovepress.com/gentamicin-coating-of-nanotubular-anodized-titanium-implant-reduces-im-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Denghui Liu,1,* Chongru He,2,* Zhongtang Liu,2 Weidong Xu2 1Department of Orthopedics, the 113 Military Hospital, Ningbo, 2Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Titanium and titanium alloy are widely used as orthopedic implants for their favorable mechanical properties and satisfactory biocompatibility. The aim of the present study was to investigate the antibacterial effect and bone cell biocompatibility of a novel implant made with nanotubular anodized titanium coated with gentamicin (NTATi-G) through in vivo study in rabbits. The animals were divided into four groups, each receiving different kinds of implants, that is, NTATi-G, titanium coated with gentamicin (Ti-G), nanotubular anodized titanium uncoated with gentamicin (NTATi) and titanium uncoated with gentamicin (Ti). The results showed that NTATi-G implant prevented implant-related osteomyelitis and enhanced bone biocompatibility in vivo. Moreover, the body temperature of rabbits in NTATi-G and Ti-G groups was lower than those in Ti groups, while the weight of rabbits in NTATi-G and Ti-G groups was heavier than those in NTATi and Ti groups, respectively. White blood cell counts in NTATi-G group were lower than NTATi and Ti groups. Features of myelitis were observed by X-ray films in the NTATi and Ti groups, but not in the NTATi-G and Ti-G groups. The radiographic scores, which assessed pathology and histopathology in bone tissues, were significantly lower in the NTATi-G and Ti-G groups than those in the NTATi and Ti groups, respectively (P<0.05). Meanwhile, explants and bone tissue culture demonstrated significantly less bacterial growth in the NTATi-G and Ti-G groups than in the NTATi and Ti groups, respectively (P<0.01). The bone volume in NTATi-G group was greater than Ti-G group, and little bone formation was seen in NTATi and Ti groups. Keywords: nanotubular anodized titanium, gentamicin, titanium implant, infection, antibioticLiu DHe CLiu ZXu WDove Medical Pressarticlenanotubular anodized titaniumgentamicintitanium implantinfectionantibioticMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5461-5471 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanotubular anodized titanium gentamicin titanium implant infection antibiotic Medicine (General) R5-920
spellingShingle	nanotubular anodized titanium gentamicin titanium implant infection antibiotic Medicine (General) R5-920 Liu D He C Liu Z Xu W Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
description	Denghui Liu,1,* Chongru He,2,* Zhongtang Liu,2 Weidong Xu2 1Department of Orthopedics, the 113 Military Hospital, Ningbo, 2Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Titanium and titanium alloy are widely used as orthopedic implants for their favorable mechanical properties and satisfactory biocompatibility. The aim of the present study was to investigate the antibacterial effect and bone cell biocompatibility of a novel implant made with nanotubular anodized titanium coated with gentamicin (NTATi-G) through in vivo study in rabbits. The animals were divided into four groups, each receiving different kinds of implants, that is, NTATi-G, titanium coated with gentamicin (Ti-G), nanotubular anodized titanium uncoated with gentamicin (NTATi) and titanium uncoated with gentamicin (Ti). The results showed that NTATi-G implant prevented implant-related osteomyelitis and enhanced bone biocompatibility in vivo. Moreover, the body temperature of rabbits in NTATi-G and Ti-G groups was lower than those in Ti groups, while the weight of rabbits in NTATi-G and Ti-G groups was heavier than those in NTATi and Ti groups, respectively. White blood cell counts in NTATi-G group were lower than NTATi and Ti groups. Features of myelitis were observed by X-ray films in the NTATi and Ti groups, but not in the NTATi-G and Ti-G groups. The radiographic scores, which assessed pathology and histopathology in bone tissues, were significantly lower in the NTATi-G and Ti-G groups than those in the NTATi and Ti groups, respectively (P<0.05). Meanwhile, explants and bone tissue culture demonstrated significantly less bacterial growth in the NTATi-G and Ti-G groups than in the NTATi and Ti groups, respectively (P<0.01). The bone volume in NTATi-G group was greater than Ti-G group, and little bone formation was seen in NTATi and Ti groups. Keywords: nanotubular anodized titanium, gentamicin, titanium implant, infection, antibiotic
format	article
author	Liu D He C Liu Z Xu W
author_facet	Liu D He C Liu Z Xu W
author_sort	Liu D
title	Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
title_short	Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
title_full	Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
title_fullStr	Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
title_full_unstemmed	Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
title_sort	gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/052aeef4e9a44e1ca9244adb198facd3
work_keys_str_mv	AT liud gentamicincoatingofnanotubularanodizedtitaniumimplantreducesimplantrelatedosteomyelitisandenhancesbonebiocompatibilityinrabbits AT hec gentamicincoatingofnanotubularanodizedtitaniumimplantreducesimplantrelatedosteomyelitisandenhancesbonebiocompatibilityinrabbits AT liuz gentamicincoatingofnanotubularanodizedtitaniumimplantreducesimplantrelatedosteomyelitisandenhancesbonebiocompatibilityinrabbits AT xuw gentamicincoatingofnanotubularanodizedtitaniumimplantreducesimplantrelatedosteomyelitisandenhancesbonebiocompatibilityinrabbits
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Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

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