Display of the human mucinome with defined O-glycans by gene engineered cells
Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures to dissect the functions of TR O-glycosylation.
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Nature Portfolio
2021
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oai:doaj.org-article:052ba3410c8a4710a0be9d4b267f2de32021-12-02T14:34:12ZDisplay of the human mucinome with defined O-glycans by gene engineered cells10.1038/s41467-021-24366-42041-1723https://doaj.org/article/052ba3410c8a4710a0be9d4b267f2de32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24366-4https://doaj.org/toc/2041-1723Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures to dissect the functions of TR O-glycosylation.Rebecca NasonChristian BüllAndriana KonstantinidiLingbo SunZilu YeAdnan HalimWenjuan DuDaniel M. SørensenFabien DurbessonSanae FurukawaUlla MandelHiren J. JoshiLeo Alexander DworkinLars HansenLeonor DavidTina M. IversonBarbara A. BensingPaul M. SullamAjit VarkiErik de VriesCornelis A. M. de HaanRenaud VincentelliBernard HenrissatSergey Y. VakhrushevHenrik ClausenYoshiki NarimatsuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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EN |
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Science Q |
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Science Q Rebecca Nason Christian Büll Andriana Konstantinidi Lingbo Sun Zilu Ye Adnan Halim Wenjuan Du Daniel M. Sørensen Fabien Durbesson Sanae Furukawa Ulla Mandel Hiren J. Joshi Leo Alexander Dworkin Lars Hansen Leonor David Tina M. Iverson Barbara A. Bensing Paul M. Sullam Ajit Varki Erik de Vries Cornelis A. M. de Haan Renaud Vincentelli Bernard Henrissat Sergey Y. Vakhrushev Henrik Clausen Yoshiki Narimatsu Display of the human mucinome with defined O-glycans by gene engineered cells |
| description |
Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures to dissect the functions of TR O-glycosylation. |
| format |
article |
| author |
Rebecca Nason Christian Büll Andriana Konstantinidi Lingbo Sun Zilu Ye Adnan Halim Wenjuan Du Daniel M. Sørensen Fabien Durbesson Sanae Furukawa Ulla Mandel Hiren J. Joshi Leo Alexander Dworkin Lars Hansen Leonor David Tina M. Iverson Barbara A. Bensing Paul M. Sullam Ajit Varki Erik de Vries Cornelis A. M. de Haan Renaud Vincentelli Bernard Henrissat Sergey Y. Vakhrushev Henrik Clausen Yoshiki Narimatsu |
| author_facet |
Rebecca Nason Christian Büll Andriana Konstantinidi Lingbo Sun Zilu Ye Adnan Halim Wenjuan Du Daniel M. Sørensen Fabien Durbesson Sanae Furukawa Ulla Mandel Hiren J. Joshi Leo Alexander Dworkin Lars Hansen Leonor David Tina M. Iverson Barbara A. Bensing Paul M. Sullam Ajit Varki Erik de Vries Cornelis A. M. de Haan Renaud Vincentelli Bernard Henrissat Sergey Y. Vakhrushev Henrik Clausen Yoshiki Narimatsu |
| author_sort |
Rebecca Nason |
| title |
Display of the human mucinome with defined O-glycans by gene engineered cells |
| title_short |
Display of the human mucinome with defined O-glycans by gene engineered cells |
| title_full |
Display of the human mucinome with defined O-glycans by gene engineered cells |
| title_fullStr |
Display of the human mucinome with defined O-glycans by gene engineered cells |
| title_full_unstemmed |
Display of the human mucinome with defined O-glycans by gene engineered cells |
| title_sort |
display of the human mucinome with defined o-glycans by gene engineered cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/052ba3410c8a4710a0be9d4b267f2de3 |
| work_keys_str_mv |
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| _version_ |
1718391111693631488 |