Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinet...

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Autores principales:	Choi SJ, Choy JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/052fff9ba1514533bb473d2c1ac4d80f
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spelling	oai:doaj.org-article:052fff9ba1514533bb473d2c1ac4d80f2021-12-02T01:38:46ZBiokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction1178-2013https://doaj.org/article/052fff9ba1514533bb473d2c1ac4d80f2014-12-01T00:00:00Zhttp://www.dovepress.com/biokinetics-of-zinc-oxide-nanoparticles-toxicokinetics-biological-fate-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interactionChoi SJChoy JHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 2, Pp 261-269 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Choi SJ Choy JH Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
description	Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction
format	article
author	Choi SJ Choy JH
author_facet	Choi SJ Choy JH
author_sort	Choi SJ
title	Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
title_short	Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
title_full	Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
title_fullStr	Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
title_full_unstemmed	Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
title_sort	biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/052fff9ba1514533bb473d2c1ac4d80f
work_keys_str_mv	AT choisj biokineticsofzincoxidenanoparticlestoxicokineticsbiologicalfatesandproteininteraction AT choyjh biokineticsofzincoxidenanoparticlestoxicokineticsbiologicalfatesandproteininteraction
_version_	1718402938545635328

Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

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