Ambient oxygen promotes tumorigenesis.
Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that ambient oxygen can also cause genomic instability in cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level is unclear. Herei...
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Public Library of Science (PLoS)
2011
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oai:doaj.org-article:053088453a644174baa3e73f90b6fae02021-11-18T06:54:06ZAmbient oxygen promotes tumorigenesis.1932-620310.1371/journal.pone.0019785https://doaj.org/article/053088453a644174baa3e73f90b6fae02011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589870/?tool=EBIhttps://doaj.org/toc/1932-6203Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that ambient oxygen can also cause genomic instability in cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level is unclear. Herein, by decreasing ambient oxygen exposure, we report a ∼50% increase in the median tumor-free survival time of p53-/- mice. In the thymus, reducing oxygen exposure decreased the levels of oxidative DNA damage and RAG recombinase, both of which are known to promote lymphomagenesis in p53-/- mice. Oxygen is further shown to be associated with genomic instability in two additional cancer models involving the APC tumor suppressor gene and chemical carcinogenesis. Together, these observations represent the first report directly testing the effect of ambient oxygen on de novo tumorigenesis and provide important physiologic evidence demonstrating its critical role in increasing genomic instability in vivo.Ho Joong SungWenzhe MaMatthew F StarostCory U LagoPhilip K LimMichael N SackJu-Gyeong KangPing-yuan WangPaul M HwangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19785 (2011) |
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DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Ho Joong Sung Wenzhe Ma Matthew F Starost Cory U Lago Philip K Lim Michael N Sack Ju-Gyeong Kang Ping-yuan Wang Paul M Hwang Ambient oxygen promotes tumorigenesis. |
| description |
Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that ambient oxygen can also cause genomic instability in cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level is unclear. Herein, by decreasing ambient oxygen exposure, we report a ∼50% increase in the median tumor-free survival time of p53-/- mice. In the thymus, reducing oxygen exposure decreased the levels of oxidative DNA damage and RAG recombinase, both of which are known to promote lymphomagenesis in p53-/- mice. Oxygen is further shown to be associated with genomic instability in two additional cancer models involving the APC tumor suppressor gene and chemical carcinogenesis. Together, these observations represent the first report directly testing the effect of ambient oxygen on de novo tumorigenesis and provide important physiologic evidence demonstrating its critical role in increasing genomic instability in vivo. |
| format |
article |
| author |
Ho Joong Sung Wenzhe Ma Matthew F Starost Cory U Lago Philip K Lim Michael N Sack Ju-Gyeong Kang Ping-yuan Wang Paul M Hwang |
| author_facet |
Ho Joong Sung Wenzhe Ma Matthew F Starost Cory U Lago Philip K Lim Michael N Sack Ju-Gyeong Kang Ping-yuan Wang Paul M Hwang |
| author_sort |
Ho Joong Sung |
| title |
Ambient oxygen promotes tumorigenesis. |
| title_short |
Ambient oxygen promotes tumorigenesis. |
| title_full |
Ambient oxygen promotes tumorigenesis. |
| title_fullStr |
Ambient oxygen promotes tumorigenesis. |
| title_full_unstemmed |
Ambient oxygen promotes tumorigenesis. |
| title_sort |
ambient oxygen promotes tumorigenesis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/053088453a644174baa3e73f90b6fae0 |
| work_keys_str_mv |
AT hojoongsung ambientoxygenpromotestumorigenesis AT wenzhema ambientoxygenpromotestumorigenesis AT matthewfstarost ambientoxygenpromotestumorigenesis AT coryulago ambientoxygenpromotestumorigenesis AT philipklim ambientoxygenpromotestumorigenesis AT michaelnsack ambientoxygenpromotestumorigenesis AT jugyeongkang ambientoxygenpromotestumorigenesis AT pingyuanwang ambientoxygenpromotestumorigenesis AT paulmhwang ambientoxygenpromotestumorigenesis |
| _version_ |
1718424209198153728 |