Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx

Human Immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) succeed to evade host immune defenses by using their viral auxiliary proteins to antagonize host restriction factors. HIV-2/SIVsmm Vpx is known for degrading SAMHD1, a factor impeding the reverse transcription. More recently, Vpx was also...

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Autores principales: Michaël M. Martin, Roy Matkovic, Pauline Larrous, Marina Morel, Angélique Lasserre, Virginie Vauthier, Florence Margottin-Goguet
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/05385fe8f4224a13931c53c96d9a993f
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