A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectively masks actin filament ends to promote nucleatio...

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Autores principales: Johanna Funk, Felipe Merino, Matthias Schaks, Klemens Rottner, Stefan Raunser, Peter Bieling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0538e02cfebe46a795c981704bc20703
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spelling oai:doaj.org-article:0538e02cfebe46a795c981704bc207032021-12-02T14:55:15ZA barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks10.1038/s41467-021-25682-52041-1723https://doaj.org/article/0538e02cfebe46a795c981704bc207032021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25682-5https://doaj.org/toc/2041-1723The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectively masks actin filament ends to promote nucleation.Johanna FunkFelipe MerinoMatthias SchaksKlemens RottnerStefan RaunserPeter BielingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Johanna Funk
Felipe Merino
Matthias Schaks
Klemens Rottner
Stefan Raunser
Peter Bieling
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
description The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectively masks actin filament ends to promote nucleation.
format article
author Johanna Funk
Felipe Merino
Matthias Schaks
Klemens Rottner
Stefan Raunser
Peter Bieling
author_facet Johanna Funk
Felipe Merino
Matthias Schaks
Klemens Rottner
Stefan Raunser
Peter Bieling
author_sort Johanna Funk
title A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
title_short A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
title_full A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
title_fullStr A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
title_full_unstemmed A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
title_sort barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0538e02cfebe46a795c981704bc20703
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