Risk factors for the development of bronchiectasis in patients with asthma

Abstract Though asthma and bronchiectasis are two different diseases, their coexistence has been demonstrated in many patients. The aim of the present study is to compare the characteristics of asthmatic patients with and without bronchiectasis and to assess risk factors for the development of this...

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Autores principales:	Donghai Ma, María-Jesús Cruz, Iñigo Ojanguren, Christian Romero-Mesones, Diego Varona-Porres, Xavier Munoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05393de38d814776ae86050b052bd8a9
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spelling	oai:doaj.org-article:05393de38d814776ae86050b052bd8a92021-11-28T12:18:21ZRisk factors for the development of bronchiectasis in patients with asthma10.1038/s41598-021-02332-w2045-2322https://doaj.org/article/05393de38d814776ae86050b052bd8a92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02332-whttps://doaj.org/toc/2045-2322Abstract Though asthma and bronchiectasis are two different diseases, their coexistence has been demonstrated in many patients. The aim of the present study is to compare the characteristics of asthmatic patients with and without bronchiectasis and to assess risk factors for the development of this condition. Two hundred and twenty-four moderate-severe asthmatic patients were included. The severity of bronchiectasis was assessed by Reiff and FACED parameters. Logistic regression was used to identify independent factors associated with bronchiectasis. Bronchiectasis was identified in 78 asthma patients. In severe asthma patients, its prevalence was 56.9%. Bronchiectasis was defined as mild in81% of patients using modified Reiff criteria and in 74% using FACED criteria. Asthmatic patients with bronchiectasis had decreasing FEV1, FVC and FEV1/FVC (p = 0.002, 0.005 and 0.014 respectively), presented more frequent asthma exacerbations (p < 0.001) and worse asthma control (ACT 21 vs 16pts, p < 0.001). Factors independently associated with bronchiectasis were older age (42–65 years: OR, 3.99; 95% CI 1.60 to 9.95, P = 0.003; ≥ 65 years: OR, 2.91; 95% CI 1.06 to 8.04, P = 0.039), severe asthma grade (OR, 8.91; 95% CI 3.69 to 21.49; P < 0.001) and frequency of asthma exacerbations (OR, 4.43; 95% CI 1.78 to 11.05; P < 0.001). In patients with severe asthma, age of asthma onset (OR, 1.02; 95% CI 1.01 to 1.04; P = 0.015) and asthma exacerbations (OR, 4.88; 95% CI 1.98 to 12.03; P = 0.001) were independently associated with the development of bronchiectasis. The prevalence of bronchiectasis in severe asthmatic patients is high. Age of asthma onset and exacerbations were independent factors associated with the occurrence of bronchiectasis.Donghai MaMaría-Jesús CruzIñigo OjangurenChristian Romero-MesonesDiego Varona-PorresXavier MunozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Donghai Ma María-Jesús Cruz Iñigo Ojanguren Christian Romero-Mesones Diego Varona-Porres Xavier Munoz Risk factors for the development of bronchiectasis in patients with asthma
description	Abstract Though asthma and bronchiectasis are two different diseases, their coexistence has been demonstrated in many patients. The aim of the present study is to compare the characteristics of asthmatic patients with and without bronchiectasis and to assess risk factors for the development of this condition. Two hundred and twenty-four moderate-severe asthmatic patients were included. The severity of bronchiectasis was assessed by Reiff and FACED parameters. Logistic regression was used to identify independent factors associated with bronchiectasis. Bronchiectasis was identified in 78 asthma patients. In severe asthma patients, its prevalence was 56.9%. Bronchiectasis was defined as mild in81% of patients using modified Reiff criteria and in 74% using FACED criteria. Asthmatic patients with bronchiectasis had decreasing FEV1, FVC and FEV1/FVC (p = 0.002, 0.005 and 0.014 respectively), presented more frequent asthma exacerbations (p < 0.001) and worse asthma control (ACT 21 vs 16pts, p < 0.001). Factors independently associated with bronchiectasis were older age (42–65 years: OR, 3.99; 95% CI 1.60 to 9.95, P = 0.003; ≥ 65 years: OR, 2.91; 95% CI 1.06 to 8.04, P = 0.039), severe asthma grade (OR, 8.91; 95% CI 3.69 to 21.49; P < 0.001) and frequency of asthma exacerbations (OR, 4.43; 95% CI 1.78 to 11.05; P < 0.001). In patients with severe asthma, age of asthma onset (OR, 1.02; 95% CI 1.01 to 1.04; P = 0.015) and asthma exacerbations (OR, 4.88; 95% CI 1.98 to 12.03; P = 0.001) were independently associated with the development of bronchiectasis. The prevalence of bronchiectasis in severe asthmatic patients is high. Age of asthma onset and exacerbations were independent factors associated with the occurrence of bronchiectasis.
format	article
author	Donghai Ma María-Jesús Cruz Iñigo Ojanguren Christian Romero-Mesones Diego Varona-Porres Xavier Munoz
author_facet	Donghai Ma María-Jesús Cruz Iñigo Ojanguren Christian Romero-Mesones Diego Varona-Porres Xavier Munoz
author_sort	Donghai Ma
title	Risk factors for the development of bronchiectasis in patients with asthma
title_short	Risk factors for the development of bronchiectasis in patients with asthma
title_full	Risk factors for the development of bronchiectasis in patients with asthma
title_fullStr	Risk factors for the development of bronchiectasis in patients with asthma
title_full_unstemmed	Risk factors for the development of bronchiectasis in patients with asthma
title_sort	risk factors for the development of bronchiectasis in patients with asthma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05393de38d814776ae86050b052bd8a9
work_keys_str_mv	AT donghaima riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma AT mariajesuscruz riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma AT inigoojanguren riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma AT christianromeromesones riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma AT diegovaronaporres riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma AT xaviermunoz riskfactorsforthedevelopmentofbronchiectasisinpatientswithasthma
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Risk factors for the development of bronchiectasis in patients with asthma

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