Type I interferon-mediated autoinflammation due to DNase II deficiency
Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling.
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/053d78d21e4b496886091d098bf2bf52 |
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oai:doaj.org-article:053d78d21e4b496886091d098bf2bf522021-12-02T17:06:16ZType I interferon-mediated autoinflammation due to DNase II deficiency10.1038/s41467-017-01932-32041-1723https://doaj.org/article/053d78d21e4b496886091d098bf2bf522017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01932-3https://doaj.org/toc/2041-1723Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling.Mathieu P. RoderoAlessandra TesserEva BartokGillian I. RiceErika Della MinaMarine DeppBenoit BeitzVincent BondetNicolas CagnardDarragh DuffyMichael DussiotMarie-Louise FrémondMarco GattornoFlavia GuillemNaoki KitabayashiFabrice PorcherayFrederic Rieux-LaucatLuis SeabraCarolina UggentiStefano VolpiLeo A H. ZeefMarie-Alexandra AlyanakianJacques BeltrandAnna Monica BiancoNathalie BoddaertChantal BrouzesSophie CandonRoberta CaorsiMarina CharbitMonique FabreFlavio FaletraMuriel GirardAnnie HarrocheEvelyn HartmannDominique LasneAnnalisa MarcuzziBénédicte NevenPatrick NitschkeTiffany PascreauSerena PastoreCapucine PicardPaolo PiccoElisa PiscianzMichel PolakPierre QuartierMarion RabantGabriele StoccoAndrea TaddioFlorence UettwillerErica ValencicDiego VozziGunther HartmannWinfried BarchetOlivier HermineBrigitte Bader-MeunierAlberto TommasiniYanick J. CrowNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| institution |
DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Mathieu P. Rodero Alessandra Tesser Eva Bartok Gillian I. Rice Erika Della Mina Marine Depp Benoit Beitz Vincent Bondet Nicolas Cagnard Darragh Duffy Michael Dussiot Marie-Louise Frémond Marco Gattorno Flavia Guillem Naoki Kitabayashi Fabrice Porcheray Frederic Rieux-Laucat Luis Seabra Carolina Uggenti Stefano Volpi Leo A H. Zeef Marie-Alexandra Alyanakian Jacques Beltrand Anna Monica Bianco Nathalie Boddaert Chantal Brouzes Sophie Candon Roberta Caorsi Marina Charbit Monique Fabre Flavio Faletra Muriel Girard Annie Harroche Evelyn Hartmann Dominique Lasne Annalisa Marcuzzi Bénédicte Neven Patrick Nitschke Tiffany Pascreau Serena Pastore Capucine Picard Paolo Picco Elisa Piscianz Michel Polak Pierre Quartier Marion Rabant Gabriele Stocco Andrea Taddio Florence Uettwiller Erica Valencic Diego Vozzi Gunther Hartmann Winfried Barchet Olivier Hermine Brigitte Bader-Meunier Alberto Tommasini Yanick J. Crow Type I interferon-mediated autoinflammation due to DNase II deficiency |
| description |
Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling. |
| format |
article |
| author |
Mathieu P. Rodero Alessandra Tesser Eva Bartok Gillian I. Rice Erika Della Mina Marine Depp Benoit Beitz Vincent Bondet Nicolas Cagnard Darragh Duffy Michael Dussiot Marie-Louise Frémond Marco Gattorno Flavia Guillem Naoki Kitabayashi Fabrice Porcheray Frederic Rieux-Laucat Luis Seabra Carolina Uggenti Stefano Volpi Leo A H. Zeef Marie-Alexandra Alyanakian Jacques Beltrand Anna Monica Bianco Nathalie Boddaert Chantal Brouzes Sophie Candon Roberta Caorsi Marina Charbit Monique Fabre Flavio Faletra Muriel Girard Annie Harroche Evelyn Hartmann Dominique Lasne Annalisa Marcuzzi Bénédicte Neven Patrick Nitschke Tiffany Pascreau Serena Pastore Capucine Picard Paolo Picco Elisa Piscianz Michel Polak Pierre Quartier Marion Rabant Gabriele Stocco Andrea Taddio Florence Uettwiller Erica Valencic Diego Vozzi Gunther Hartmann Winfried Barchet Olivier Hermine Brigitte Bader-Meunier Alberto Tommasini Yanick J. Crow |
| author_facet |
Mathieu P. Rodero Alessandra Tesser Eva Bartok Gillian I. Rice Erika Della Mina Marine Depp Benoit Beitz Vincent Bondet Nicolas Cagnard Darragh Duffy Michael Dussiot Marie-Louise Frémond Marco Gattorno Flavia Guillem Naoki Kitabayashi Fabrice Porcheray Frederic Rieux-Laucat Luis Seabra Carolina Uggenti Stefano Volpi Leo A H. Zeef Marie-Alexandra Alyanakian Jacques Beltrand Anna Monica Bianco Nathalie Boddaert Chantal Brouzes Sophie Candon Roberta Caorsi Marina Charbit Monique Fabre Flavio Faletra Muriel Girard Annie Harroche Evelyn Hartmann Dominique Lasne Annalisa Marcuzzi Bénédicte Neven Patrick Nitschke Tiffany Pascreau Serena Pastore Capucine Picard Paolo Picco Elisa Piscianz Michel Polak Pierre Quartier Marion Rabant Gabriele Stocco Andrea Taddio Florence Uettwiller Erica Valencic Diego Vozzi Gunther Hartmann Winfried Barchet Olivier Hermine Brigitte Bader-Meunier Alberto Tommasini Yanick J. Crow |
| author_sort |
Mathieu P. Rodero |
| title |
Type I interferon-mediated autoinflammation due to DNase II deficiency |
| title_short |
Type I interferon-mediated autoinflammation due to DNase II deficiency |
| title_full |
Type I interferon-mediated autoinflammation due to DNase II deficiency |
| title_fullStr |
Type I interferon-mediated autoinflammation due to DNase II deficiency |
| title_full_unstemmed |
Type I interferon-mediated autoinflammation due to DNase II deficiency |
| title_sort |
type i interferon-mediated autoinflammation due to dnase ii deficiency |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/053d78d21e4b496886091d098bf2bf52 |
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