Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology

Abstract Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the current...

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Autores principales:	Samira M. Hamed, Walid F. Elkhatib, Ahmed S. Khairalla, Ayman M. Noreddin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/053d96849e7b431798621682744a9c55
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spelling	oai:doaj.org-article:053d96849e7b431798621682744a9c552021-12-02T17:32:57ZGlobal dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology10.1038/s41598-021-87713-x2045-2322https://doaj.org/article/053d96849e7b431798621682744a9c552021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87713-xhttps://doaj.org/toc/2045-2322Abstract Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH. Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months. D614G clades prevail in countries with more COVID-19 cases. Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases. In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease. Metadata analysis showed higher (p < 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. Higher prevalence of the GV clade in children compared to other age groups was also evident. These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality.Samira M. HamedWalid F. ElkhatibAhmed S. KhairallaAyman M. NoreddinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samira M. Hamed Walid F. Elkhatib Ahmed S. Khairalla Ayman M. Noreddin Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
description	Abstract Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH. Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months. D614G clades prevail in countries with more COVID-19 cases. Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases. In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease. Metadata analysis showed higher (p < 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. Higher prevalence of the GV clade in children compared to other age groups was also evident. These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality.
format	article
author	Samira M. Hamed Walid F. Elkhatib Ahmed S. Khairalla Ayman M. Noreddin
author_facet	Samira M. Hamed Walid F. Elkhatib Ahmed S. Khairalla Ayman M. Noreddin
author_sort	Samira M. Hamed
title	Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
title_short	Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
title_full	Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
title_fullStr	Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
title_full_unstemmed	Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
title_sort	global dynamics of sars-cov-2 clades and their relation to covid-19 epidemiology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/053d96849e7b431798621682744a9c55
work_keys_str_mv	AT samiramhamed globaldynamicsofsarscov2cladesandtheirrelationtocovid19epidemiology AT walidfelkhatib globaldynamicsofsarscov2cladesandtheirrelationtocovid19epidemiology AT ahmedskhairalla globaldynamicsofsarscov2cladesandtheirrelationtocovid19epidemiology AT aymanmnoreddin globaldynamicsofsarscov2cladesandtheirrelationtocovid19epidemiology
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Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology

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