An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features

Lymphoproliferative disorders (LPD) are conditions characterized by the uncontrolled proliferation of B or T-cell lines. They encompass a wide spectrum of abnormalities, which may be broadly classified as reactive processes or malignant diseases, such as lymphoma, based on their cellular clonality a...

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Autores principales: Ahmed Ebada Salem, Yehia H. Zaki, Gamal El-Hussieny, Khaled I. ElNoueam, Akram M. Shaaban, Bhasker Rao Koppula, Mark Bustoros, Mohamed Salama, Khaled M. Elsayes, Kathryn Morton, Matthew F. Covington
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:053d973fce5b4c499accbea9950333f02021-11-25T17:04:45ZAn Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features10.3390/cancers132258532072-6694https://doaj.org/article/053d973fce5b4c499accbea9950333f02021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5853https://doaj.org/toc/2072-6694Lymphoproliferative disorders (LPD) are conditions characterized by the uncontrolled proliferation of B or T-cell lines. They encompass a wide spectrum of abnormalities, which may be broadly classified as reactive processes or malignant diseases, such as lymphoma, based on their cellular clonality and clinical behavior. While some of these disorders are rare, they may be encountered sporadically in clinical practice, causing diagnostic dilemmas owing to overlap in their clinical and imaging features with more common disorders. The updated 4th edition WHO classification of lymphoid neoplasms was released in 2016 to incorporate the rapid clinical, pathological, molecular biology and cytogenetic advances of some of these disorders. Despite these updates, very little information is presented in the literature from the radiology perspective. The aim of this article is to familiarize radiologists and other physicians with certain rare variants of B-cell lymphoproliferative disorders with a focus on imaging features of these disorders, as well as to provide an overview of some important updates contained within the new WHO classification of lymphoid neoplasms.Ahmed Ebada SalemYehia H. ZakiGamal El-HussienyKhaled I. ElNoueamAkram M. ShaabanBhasker Rao KoppulaMark BustorosMohamed SalamaKhaled M. ElsayesKathryn MortonMatthew F. CovingtonMDPI AGarticleupdatesWHO classification of hematologic malignancieslymphoproliferative disordersrare B-cell lymphomas18F-FDG PET/CTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5853, p 5853 (2021)
institution DOAJ
collection DOAJ
language EN
topic updates
WHO classification of hematologic malignancies
lymphoproliferative disorders
rare B-cell lymphomas
18F-FDG PET/CT
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle updates
WHO classification of hematologic malignancies
lymphoproliferative disorders
rare B-cell lymphomas
18F-FDG PET/CT
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Ahmed Ebada Salem
Yehia H. Zaki
Gamal El-Hussieny
Khaled I. ElNoueam
Akram M. Shaaban
Bhasker Rao Koppula
Mark Bustoros
Mohamed Salama
Khaled M. Elsayes
Kathryn Morton
Matthew F. Covington
An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
description Lymphoproliferative disorders (LPD) are conditions characterized by the uncontrolled proliferation of B or T-cell lines. They encompass a wide spectrum of abnormalities, which may be broadly classified as reactive processes or malignant diseases, such as lymphoma, based on their cellular clonality and clinical behavior. While some of these disorders are rare, they may be encountered sporadically in clinical practice, causing diagnostic dilemmas owing to overlap in their clinical and imaging features with more common disorders. The updated 4th edition WHO classification of lymphoid neoplasms was released in 2016 to incorporate the rapid clinical, pathological, molecular biology and cytogenetic advances of some of these disorders. Despite these updates, very little information is presented in the literature from the radiology perspective. The aim of this article is to familiarize radiologists and other physicians with certain rare variants of B-cell lymphoproliferative disorders with a focus on imaging features of these disorders, as well as to provide an overview of some important updates contained within the new WHO classification of lymphoid neoplasms.
format article
author Ahmed Ebada Salem
Yehia H. Zaki
Gamal El-Hussieny
Khaled I. ElNoueam
Akram M. Shaaban
Bhasker Rao Koppula
Mark Bustoros
Mohamed Salama
Khaled M. Elsayes
Kathryn Morton
Matthew F. Covington
author_facet Ahmed Ebada Salem
Yehia H. Zaki
Gamal El-Hussieny
Khaled I. ElNoueam
Akram M. Shaaban
Bhasker Rao Koppula
Mark Bustoros
Mohamed Salama
Khaled M. Elsayes
Kathryn Morton
Matthew F. Covington
author_sort Ahmed Ebada Salem
title An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
title_short An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
title_full An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
title_fullStr An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
title_full_unstemmed An Overview of Selected Rare B-Cell Lymphoproliferative Disorders: Imaging, Histopathologic, and Clinical Features
title_sort overview of selected rare b-cell lymphoproliferative disorders: imaging, histopathologic, and clinical features
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/053d973fce5b4c499accbea9950333f0
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